🕊️ PEACE Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
⚙️ influence of #ECLS circuit & components
💉 anticoagulant medications
🎯 monitoring & targets
🧪 monitoring & replacement of AT, fibrinogen, vWF
💉 antifibrinolytic & adjunct hemostatic agents
🔪 perioperative period
🩸 bleeding & thrombotic complications
🔍 priorities for clinical Research
#FOAMcc #FOAMecmo #PedsICU
Summary 🔓 https://bit.ly/3RU7l5c
& special issue 🔓 https://bit.ly/3XVOqL7

Investigating/characterizing platelet & leukocyte adsorption in #ECMO circuits
💡detailed protocol utilizing immunofluorescence to help extend knowledge in binding mechanisms + pathophysiology of adsorption, providing guidance for better circuit design. Protocol enabling comprehensive characterization of cellular binding to circuits collected from patients, could also be adapted to circuit binding studies of other #ECLS systems, such as #CPB, #VAD, #RRT devices.
🖇️ https://bit.ly/3XK4oYD

Acquired von Willebrand syndrome in #ECMO support, review of current evidence
🔍 prevalence of AVWS in #ECLS children & adults
🩸 bleeding complications in AVWS
⚙️ management
💉 desmopressin & VWF-containing concentrates.
🛑 inhibition of ADAMTS-13-mediated proteolysis of VWF
Limited evidence & need for a consensus definition, but data suggest almost all pts develop partial/complete loss of VWF HMW multimers within hours since initiation; weaning completely resolves AVWS.
🖇️ https://bit.ly/3RK3OGp

Thrombolysis before VA #ECMO cannulation in high-risk pulmonary embolism
🔍 72 high-risk PE pts; 43% underwent pre-ECMO thrombolysis
🩸incidence of moderate-to-severe bleeding notably elevated in both groups
🪦 no difference in 90-day survival if systemic thrombolysis or not
🗓️ long-term QoL acceptable; no chronic thromboembolic pulmonary hypertension
Recent systemic thrombolysis, as a single parameter, should not be considered contraindication for #ECLS in this population
🔓 https://rdcu.be/dLOBk

📢 The June 2024 ELSO newsletter is out! DoN'T miss:
🖋️ Message from our President, Graeme MacLaren
🛏 Bedside with Dr Bartlett: why we have gas blender in the sweep gas?? Answer is different for VV & VA #ECMO
🎓 ELSO Academy: the Neonatal & Pediatric Foundations training course
🌏 #ECLS around the world, updates from ELSO Chapters including next annual meetings & conferences
📃 News from ELSO Committees
🖋️ CEO Christine Stead remarks & more! Read all on ELSO website at
🔗 bit.ly/2IR8RCl

Mechanical circulatory support in cardiogenic shock:
🏛️ VA #ECMO to be consigned to the museum? NO: systematic use of #ECLS in AMICS not supported, but is useful as optimal therapies fail
🔍 available evidence & need for: real benefit of ECMO difficult to show in RCTs, especially as will likely continue to be used as rescue strategy
🪡 personalize management! Both VA-ECMO & MFP have a role in severe CS: select most appropriate #MCS for the specific patient
🔓 https://rdcu.be/dLt6T

Consumptive coagulopathy during #ECLS
🔎 close monitoring & follow up pivotal during the #ECMO run
⛔️ giving platelets/clotting factors to fix numbers often worsens underlying process
🩸 low doses of anticoagulants may protect both circuit (vs thrombotic complications) & patient (vs bleeding & thrombosis)
⛔️ bleeding complications should NOT always prompt complete cessation of UFH
Detailed underlying pathophysiological process & physiological rationale free to read #FOAMcc
🔓 https://rdcu.be/dLmXO

Beyond VA & VV #ECMO, novel, alternative cannulation strategies to address unique factors related to individual cases when traditional configuration are not enough...
🫁 parallel VV circuits: to provide higher EBF/CO2 clearance in patients with ARDS with high CO & VO2
🫁🫀veno-venopulmonary #ECLS: added benefit of RV support
🫀 LAVA ECMO: biventricular support with biatrial unloading
🫀 LV apical insertion of dual-lumen cannula if significant peripheral vascular disease
🖇️ https://bit.ly/3zk1O0Y

📢 Unmissable opportunity if you want to learn everything about VV (dual site + bicaval-dual lumen) & VA #ECLS cannulation 📢
Some (few) spots still available for ELSO #ECMO Cannulation Workshop on June 23!
A hands-on event aimed to learn how to safely perform percutaneous cannulation with a team of international experts... Register NOW ‼️
🔗 https://bit.ly/3sUQcPq
🎓 Adult #cannulation workshop
🗺️ ELSO Headquarters, Ann Arbor MI
🗓️ June 23 2024 (1 one day session)
📫 [email protected]