#Malaria blood stage parasites ingest host cell contents via an
#endocytic process. This @BNITM_de study shows that the highly
#parasite-specific upstream uptake system feeds into a more canonical Rbsn5/VPS45/Rab5b-dependent
#endosomal pathway
#PLOSBiology https://plos.io/456iuFc 
Role of Rabenosyn-5 and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites
Malaria blood stage parasites ingest most of their host cell contents via an endocytic process. This study shows that despite a repurposing of many typical endosomal proteins for secretion, the highly parasite-specific upstream uptake system feeds into a more canonical Rbsn5/VPS45/Rab5b-dependent endosomal pathway.
Endosomal stress, a newly defined organelle stress, induces inflammation via ubiquitin signaling
The endosome is an essential organelle located at the center of membrane traffic and mainly sorts plasma membrane proteins internalized by endocytosis in cooperation with ubiquitination, especially lysine-63-linked polyubiquitin chains (K63 ubiquitin chains).
HEATR5B associates with
#dynein-
#dynactin and promotes motility of AP1-bound
#endosomal membranes
Simon Bullock11 and colleagues
@mrc_lmb https://www.embopress.org/doi/full/10.15252/embj.2023114473#Interferon-inducible #phospholipids govern #IFITM3-dependent #endosomal #antiviral immunity
#Phosphatidylinositol(3,4,5)-trisphosphate enhances inhibition of #endocytic viral entry via binding to the intracellular loop of interferon-induced transmembrane protein 3
Anna Kajaste-Rudnitski, Giulia Unali et al
https://www.embopress.org/doi/10.15252/embj.2022112234
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