Role of Rabenosyn-5 and Rab5b in host cell cytosol uptake reveals conservation of endosomal transport in malaria parasites

Malaria blood stage parasites ingest most of their host cell contents via an endocytic process. This study shows that despite a repurposing of many typical endosomal proteins for secretion, the highly parasite-specific upstream uptake system feeds into a more canonical Rbsn5/VPS45/Rab5b-dependent endosomal pathway.