SciTech Chronicles. . . . . . . . .May 15th, 2025

Meet the New Boss... Same as the Old Boss Vol II No 38 515 links Curated Mission Control RSS Feed Wordpress SubStack Comments Buy Me A Co...

Crystals of His15 acetamide-modified lysozyme had similar unit-cell parameters to the unmodified tetragonal form but refinement was only possible in an orthorhombic system #AcylatedLysozyme #Crystallization #SpaceGroupAnalysis https://doi.org/10.1107/S2053230X2500010X
The structure of His15 acetamide-modified hen egg-white lysozyme: a nice surprise from an old friend

Chemical modification of lysozyme at His15 using iodoacetamide was investigated structurally. Crystallization of the chemically modified enzyme using a protocol which yields tetragonal crystals gave orthorhombic crystals with similar unit-cell parameters.

Acta Crystallographica Section F
Unlike other serpins, human serpin B9 shows significant structural deviations around helix D, with a larger surface cavity, which could serve as a promising target for small-molecule inhibitors #Serpins #XRayCrystallography #Crystallization https://t.co/ilB7Aa3Krg
Crystallization and crystallographic studies of human serine protease inhibitor (serpin) B9

This study successfully determined the crystal structure of human serpin B9 at 1.9 Å resolution and identified notable structural differences surrounding helix D, providing a potential target for the development of anticancer therapeutics.

Acta Crystallographica Section F
Three deep-learning tools, referred to collectively as CHiMP, were created for analysis of micrographs of protein crystallization experiments at the DLS synchrotron, UK. #Crystallization #ImageClassification #ObjectDetection https://doi.org/10.1107/S2059798324009276
CHiMP: deep-learning tools trained on protein crystallization micrographs to enable automation of experiments

A description is given of new deep-learning tools that analyse experimental micrographs of crystallization experiments to enable the automation of outcome classification, crystal detection and determination of locations to dispense compounds for fragment-based drug discovery at Diamond Light Source.

Acta Crystallographica Section D
Patterns of Crystallization by Eris And AI

Patterns of Crystallization Digital Art by Eris And AI

Fine Art America
❄️🧊 Rime #ice (also called “rimfrost” in Swedish 🇸🇪) #icetodon #winter #nature #snow #weather #tuesday #photography #Crystallization
🧪🔬🧊 Growing sodium chloride #salt #crystals. Here is a flat crystal, ~7.2 millimetres wide, seen with optical microscopy at 10X, 40X, 200X, and 400X. At high magnifications, we can see small crystalline domains in a highly ordered arrangement. #crystallization #science #microscopy #nature

New paper from David Baker's lab: https://doi.org/10.1038/s41563-023-01683-1
Computational design of #protein #crystals! 🤯
Spontaneous #crystallization by mixing two E. coli lysates. 🤯 🤯
Designed #protein #crystals that survive being autoclaved. 🤯 🤯 🤯

#crystallography #StructuralBiology

📌NEW PAPER📌

Lithos: https://doi.org/10.1016/j.lithos.2023.107327

3D reconstructions of #SR-uCT data reveal the complex growth history of Cpx crystals. An empirical relationship estimates the ∆T governing the #crystallization of augitic Cpx erupted at #Stromboli.

#petrology #volcanology