Disappearing Polymorph

소재과학에서 '사라지는 다형체(disappearing polymorph)'는 원래 결정 구조가 더 안정적인 다른 다형체로 변해 원형을 재현하기 어려운 현상이다. 이는 미세한 씨앗 결정이 대량의 물질 변화를 촉발해 원래 다형체가 사실상 사라진 것처럼 보이게 한다. 제약 산업에서는 이러한 현상이 약물의 효능과 생산에 큰 영향을 미치며, 특허 분쟁과 제네릭 출시 지연 문제로 이어지기도 한다. 대표 사례로 파록세틴과 리토나비르 등이 있으며, 원형 다형체 복원은 이론적으로 가능하지만 실무적으로는 매우 어렵다.

https://en.wikipedia.org/wiki/Disappearing_polymorph

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Disappearing polymorph - Wikipedia

An acylated GLP-1/GIP analogue peptide forms a uniquely porous spiral crystal structure composed of clockwise-ascending monomers in a square pattern #GLP1 #Peptides #Crystallization https://doi.org/10.1107/S2053230X26001937
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Crystallized honey ≠ spoilage; bespeaks purity. Attributes: low moisture (<18%), acidic pH (3.2-4.5), hydrogen peroxide. De-crystallization via warm water bath (<40°C). #FACTOVATE #Honey #FoodScience #Purity
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https://factovate.com/does-crystallized-honey-mean-its-spoiled
Features of sample preparation that should be considered prior to biomolecular crystallization experiments are reviewed, as described in the SAMPREP workshop during the 73rd Annual ACA Meeting #Crystallization #XRayCrystallography #StructuralBiology https://doi.org/10.1107/S2053230X25004650
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