A high-throughput behavioral screening platform for measuring chemotaxis by C. elegans

Established C. elegans chemotaxis assays depend on manual assays and worm counts that limit their scalability and reproducibility. This study develops a high-throughput platform for screening the valence of C. elegans chemotaxis to large libraries of small molecules.

New structures offer insight into how a bacterial motor powers bacterial chemotaxis, a key infectious process

Bacteria existed for millennia before humans and have been infecting us from the beginning. Although we can treat infections through pharmaceuticals, bacteria continue to become resistant to treatment thanks to their rapid evolution. Bacterial infections remain a leading cause of morbidity and mortality in 2024, resulting in nearly eight million annual deaths globally.

Kongresse und Tagungen

E. coli chemotaxis: the baffling intelligence of a single cell

Microfluidic chip reveals that bacteria swim toward large, complex polymers

Using a novel microfluidic chip, ETH researchers led by Professor Roman Stocker and Estelle Clerc have shown that bacteria not only recognize small food molecules, but also swim towards large, complex polymers. A startup is now using these findings and applying the technology to find microbes in the environment that can break down pollutants.

So finden Abwehrzellen ihr Ziel

Bei einer Infektion ist das Immunsystem in der Regel schnell zur Stelle. Fachleute haben nun einen Weg entdeckt, wie Immunzellen durch den Körper navigieren.

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Designing synthetic receptors for precise cell control

Biosensors are artificial molecular complexes designed to detect the presence of target chemicals or even biomolecules. Consequently, biosensors have become important in diagnostics and synthetic cell biology. However, typical methods for engineering biosensors focus on optimizing the interactions between static binding surfaces, and current biosensor designs can only recognize structurally well-defined molecules, which can be too rigid for "real-life" biology.