Microneedles that could revolutionize cancer immunotherapy.

Made from natural polysaccharides, the new microneedles not only deliver drugs but also activate the immune system, paving the way for more effective and less invasive anticancer therapies.

Read more: https://omniletters.com/microneedles-that-could-revolutionize-cancer-immunotherapy/

#CancerImmunotherapy #Microneedles #Immunotherapy #CancerResearch #Oncology #DrugDelivery #TransdermalDelivery #Biomaterials #Polysaccharides #Nanomedicine #science #cancer

Microneedles that could revolutionize cancer immunotherapy

Made from natural polysaccharides, the new microneedles not only deliver drugs but also activate the immune system, paving the way for more effective and less invasive anticancer therapies.

Omni Letters
Happy to finally have my last results of my PhD project published in #CarbohydratePolymers: Ionic agarose derivatives as polyelectrolytic additives for controlled drug release.

Key highlights:
⚗️ Developed anionic and cationic agarose derivatives with tuneable degrees of substitution.
💧 Integrated these materials into hydrogels and alginate micro beads to enhance drug delivery performance.
⏱️ Achieved sustained and low-burst drug release over up to 14 days with advanced kinetic modelling for accurate release characterisation.

This research contributes to the development of biocompatible and efficient drug delivery systems with customisable release profiles. It now marks an end of this part of journey, where I have learned so much!

🔗 Read more: https://doi.org/10.1016/j.carbpol.2025.124622

#ControlledRelease #DrugDelivery #Biomaterials #AgaroseDerivatives #Hydrogels #Chemistry #Polysaccharides #Science

#Okra and #Fenugreek Extracts Safely Remove #Microplastics From Water in New Texas Research

May 10, 2025

"The substances behind the slimy strings from okra and the gel from fenugreek seeds could trap microplastics better than a commonly used synthetic polymer.

"Texas researchers proposed in 2022 using these sticky #NaturalPolymers to clean up water. Now, they’ve found that okra and/or fenugreek extracts attracted and removed up to 90% of microplastics from #ocean water, #freshwater, and #groundwater.

"With funding from the U.S. Department of Energy, Rajani Srinivasan and colleagues at Tarleton State University found that the plant-based polymers from okra, fenugreek, and #tamarind stick to microplastics, clumping together and sinking for easy separation from water.

"In this next stage of the research, they have optimized the process for okra and fenugreek extracts and tested results in a variety of types of water.

"To extract the sticky plant polymers, the team soaked sliced okra pods and blended fenugreek seeds in separate containers of water overnight. Then, researchers removed the dissolved extracts from each solution and dried them into powders.

"Analyses published in the American Chemical Society journal showed that the powdered extracts contained #polysaccharides, which are natural polymers. Initial tests in pure water spiked with microplastics showed that:

- One gram of either powder in a quart (one liter) of water trapped microplastics the most effectively.
- Dried okra and fenugreek extracts removed 67% and 93%, respectively, of the plastic in an hour.
- A mixture of equal parts okra and fenugreek powder reached maximum removal efficiency (70%) within 30 minutes.
- The natural polymers performed significantly better than the synthetic, commercially available polyacrylamide polymer used in #wastewater treatment.

"Then the researchers tested the plant extracts on real microplastic-polluted water. They collected samples from waterbodies around Texas and brought them to the lab. The plant extract removal efficiency changed depending on the original water source.

"Okra worked best in ocean water (80%), fenugreek in groundwater (80-90%), and the 1:1 combination of okra and fenugreek in freshwater (77%).

"The researchers hypothesize that the natural polymers had different efficiencies because each water sample had different types, sizes and shapes of microplastics.

"Polyacrylamide, which is currently used to remove contaminants during wastewater treatment, has low toxicity, but its precursor #acrylamide is considered #toxic. Okra and fenugreek extracts could serve as #biodegradable and #nontoxic alternatives.

" 'Utilizing these plant-based extracts in water treatment will remove microplastics and other pollutants without introducing additional toxic substances to the treated water,' said Srinivasan in a media release, 'thus reducing long-term health risks to the population [and the environment].

"She had previously studied the use of food-grade plant extracts as non-toxic flocculants to remove textile-based pollutants from wastewater and thought, ‘Why not try microplastics?’"

Source:
https://www.goodnewsnetwork.org/plant-based-filter-removes-up-to-99-9-of-microplastics-from-water/

#SolarPunkSunday #PlasticPollution #Plastics #Pollution #PollutionSolutions #WaterIsLife #Remediation

Plant-Based Filter Removes Up to 99.9% of Microplastics from Water

The health of effects of ingesting microplastics are, predictably, not good, though the science is in its early stages.

Good News Network

#Postdoc opportunity (2y) studying metabolism of #polysaccharides in brown #algae
in the Brown Algal #Glycans group at #Roscoff Marine Station🪸

https://emploi.cnrs.fr/Offres/CDD/UMR8227-CECHER-004/Default.aspx?lang=EN

Portail Emploi CNRS - Offre d'emploi - Post-doctorant/post-doctorante (H/F) : métabolisme de polysaccharides chez les algues brunes

#Science = #Seaweed ...

It's as simple as that!

The clear seaweed base commonly used in lab #petri dishes is killing yeasts... some #scientists are stumped.

Two #polysaccharides—agarose and agaropectin— found in the cell walls of submersible red #algae, and the sourcing of it, has become as big a problem, as some of the big problems science is trying to solve.

https://www.science.org/content/article/bad-agar-killing-lab-yeast-around-world-where-it-coming

I am excited to share our newest publication on #agarose. First authored by my colleague at @unijena, I am happy to have contributed to this work: we present novel functional agarose gels unsing "advanced #polysaccharide #chemistry" and their characterization.

https://doi.org/10.3390/polysaccharides5030014

#biopolymer #biomaterials #mdpi #polysaccharides

Functional Agarose Hydrogels Obtained by Employing Homogeneous Synthesis Strategies

The goal of this study was to explore a route for introducing functionalities into agarose-based hydrogels to tune the physical, chemical, and biological properties. Several agarose derivatives were prepared by homogeneous synthesis, including anionic agarose sulfates (ASs), reactive azido agaroses (AZAs), and cationic agarose carbamates (ACs), as well as agarose tosylates (ATOSs) and agarose phenyl carbonates (APhCs). The products were characterized in terms of their molecular structure and solubility behavior. The results suggest that the native gel-forming ability of agarose is retained if the introduced functionalities are hydrophilic, and the overall degree of substitution is low (DS < 0.5). Thus, functional hydrogels from several agarose derivatives could be obtained. The mechanical stability of the functional hydrogels was decreased compared to native agarose gels but was still in a range that enables safe handling. An increase in mechanical strength could be achieved by blending functional agarose derivatives and agarose into composite hydrogels. Finally, it was demonstrated that the novel functional agarose hydrogels are biocompatible and can potentially stimulate interactions with cells and tissue.

MDPI
New NIOO publication: Effects of different #soil organic amendments on extracellular #polymeric substances. #sustainableagriculture #soilbacteria #soilfungi #polysaccharides #protein #soilstability
https://doi.org/10.1016/j.ejsobi.2024.103624
The Privateer web app is an innovative online tool for carbohydrate 3D structure validation that allows fast, local structure validation without the need to send any files to an external service. #Validation #Polysaccharides #Carbohydrates https://doi.org/10.1107/S2053230X24000359
Online carbohydrate 3D structure validation with the Privateer web app

The Privateer carbohydrate 3D structure-validation software is now freely available as a web app. Here, its use is described, including a practical example.

Acta Crystallographica Section F
Microfluidic chip reveals that bacteria swim toward large, complex polymers

Using a novel microfluidic chip, ETH researchers led by Professor Roman Stocker and Estelle Clerc have shown that bacteria not only recognize small food molecules, but also swim towards large, complex polymers. A startup is now using these findings and applying the technology to find microbes in the environment that can break down pollutants.

Phys.org
Busy week coming - but am definitely looking forward to next week visiting #Cambridge (UK) to discuss #amyloid #ssNMR #ECM #polysaccharides and more. Actually my first visit there, although I spent quite a few years in the 'other' Cambridge (MASS/USA). :-)