Allen Tien, MD, MHS mdlogix.com 94,698 田一彦#CannabinoidScience
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This is a new hypothesis paper...
This is a new hypothesis paper with an interesting idea about autoimmune disease. These conditions are rising nationwide and globally, and the authors suggest that the endocannabinoid system may be… | Codi Peterson | 10 comments
This is a new hypothesis paper with an interesting idea about autoimmune disease. These conditions are rising nationwide and globally, and the authors suggest that the endocannabinoid system may be playing a bigger part in that problem than we realize. The graphic shows the core idea. When the gut loses important bacteria that produce short chain fatty acids, the gut lining becomes weaker and leakier. That leakiness lets inflammatory signals escape into the bloodstream, and the body responds by making more 2 AG. In small amounts this helps maintain balance. In long term inflammation it can overshoot. The endocannabinoid system begins to downregulate and other systems drift out of balance. High 2 AG for too long can overwhelm the endocannabinoid system. Receptors like CB1, CB2 and TRPV1 start to lose sensitivity, pulling inside the cell instead of staying on the surface where they receive signals. As this happens the gut barrier becomes even looser, systemic inflammation rises, and the cycle accelerates. People with certain genes may be more vulnerable to this pattern. For them the combination of gut dysbiosis, chronic inflammation and endocannabinoid imbalance may help trigger autoimmune conditions or flare ups. This is the proposal from the paper, and the authors emphasize that it is hypothetical. Even so the general idea is useful. An ECS imbalance that begins in the gut may be a shared pathway connecting several autoimmune and inflammatory conditions including type 1 diabetes, Hashimoto’s, Addison’s disease and rheumatoid arthritis. It is not a proven mechanism. It is an early model. But it provides a clearer way to connect the microbiome, gut barrier health, inflammation and the endocannabinoid system. It also helps explain why autoimmune conditions often cluster together and why many of them appear to begin in the gut. SOURCE: Łukowski W. Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective. Front Endocrinol (Lausanne). 2025;16:1576419. Published 2025 May 29. doi:10.3389/fendo.2025.1576419 | 10 comments on LinkedIn
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There are numerous cannabinoids, on the order of 100, with a range of pharmacological effects, including interactions with endogenous #Opioids, other systems
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RE: https://bsky.app/profile/did:plc:vekvoicolbqvkmur5k55cpr4/post/3m4ykx73pxk23
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Yo, even though people often s...
Yo, even though people often s...
Yo, even though people often say “cannabinoids are anti-inflammatory”, the truth is that THC probably isn’t a powerful anti-inflammatory drug. CBD, on the other hand actually has some evidence… | Codi Peterson
Yo, even though people often say “cannabinoids are anti-inflammatory”, the truth is that THC probably isn’t a powerful anti-inflammatory drug. CBD, on the other hand actually has some evidence suggesting it might be quite anti-inflammatory (but don’t come at me asking for the mechanisms, because as I mentioned in earlier posts we still don’t really know)! The image below shows a few of the proposed anti-inflammatory pathways for CBD -- including TRPV1 activation, NADPH oxidase modulation, and the NRF2 axis. If you're like me and thinking "wtf is that" i do a quick description below - TRPV1 (aka the “hot chili pepper” receptor) detects heat and chemical irritants. When activated by CBD, it may reduce the release of pro-inflammatory neuropeptides and shift pain signaling. NADPH oxidase is an enzyme complex that produces reactive oxygen species (i.e ROS). CBD appears to dampen this enzyme’s activity, limiting oxidative stress, which is a key driver of inflammation. NRF2 is a transcription factor that turns on the body’s antioxidant defense genes. CBD may enhance this pathway, neutralizing ROS and restoring the redox balance during inflammation. SOURCE: Urlić H, Kumrić M, Pavlović N, Dujić G, Dujić Ž, Božić J. Cardiovascular Effects of Cannabidiol: From Molecular Mechanisms to Clinical Implementation. Int J Mol Sci. 2025;26(19):9610. Published 2025 Oct 1. doi:10.3390/ijms26199610
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Throwing it back to another hi...
Throwing it back to another hi...
Throwing it back to another hit infographic from The Cannigma Should we to update this to include flavorants like cannasulfur compounds (CSCs), and maybe even some newly discovered alkaloids?! | Codi Peterson
Throwing it back to another hit infographic from The Cannigma Should we to update this to include flavorants like cannasulfur compounds (CSCs), and maybe even some newly discovered alkaloids?!
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High-THC cannabis linked to ps...
High-THC cannabis linked to ps...
High-THC cannabis linked to psychosis, addiction: study | Richard J. Baum posted on the topic | LinkedIn
“Cannabis products containing high concentrations of delta-9-tetrahydrocannabinol (THC) -- the main psychoactive compound in marijuana -- were linked to psychosis, schizophrenia, and addiction, a systematic review found. Across 99 studies examining the effects of high-concentration THC products on mental health outcomes, 70% of the nontherapeutic studies (i.e., those not attempting to treat a medical condition or symptom) showed an unfavorable association with psychosis or schizophrenia and 75% found a relationship to cannabis use disorder (CUD). Anxiety and depression appeared to be worsened in 53% and 41% of such studies, respectively, with even higher rates when studying healthy individuals specifically, reported Jonathan M. Samet, MD, of the Colorado School of Public Health in Aurora, and co-authors, writing in the Annals of Internal Medicine.opens in a new tab or window The findings complement those of prior systematic reviewsopens in a new tab or window in "reinforcing the conclusionopens in a new tab or window that higher THC concentrations increase the risk for adverse mental health outcomes, particularly for psychosis or schizophrenia (in both healthy persons and those with preexisting psychosis) and CUD.” #Marijuana #Cannabis #THC