Walter Chan, MD, MPHApr 11, 2023

What is the national burden of #dysphagia attributable to #opioid-induced esophageal dysfunction?

Our new study in #CTGJournal found NO correlation between opioid use & ambulatory visits for dysphagia

➡️Opioid-related manometry changes may be clinically relevant only in a subset of patients

🔗https://doi.org/10.14309/ctg.0000000000000552

Association Between Opioid Use and Outpatient Visits for... : Clinical and Translational Gastroenterology

relationship between opioid use and outpatient visits for dysphagia. RESULTS: After controlling for potential confounders, there were no significant difference in ambulatory visits for dysphagia between opioid users and nonusers (adjusted odds ratio = 0.98, confidence interval: 0.59–1.65). DISCUSSION: No correlation between opioid use and ambulatory visits for dysphagia was found in a nationwide sample. Opioid-related manometric changes may be clinically relevant only in a small proportion of patients....

LWW
Walter Chan, MD, MPHDec 12, 2022

Our new study in this issue of #CTGJournal analyzed gene transcript expressions on mucosal biopsies of patients with eosinophilic esophagitis (#EoE)

🧬Transcript profiles similar between PPI-responsive (PPI-R) & non-responsive (PPI-NR) EoE
🧬PPI-R EoE shares Th2 inflammatory signature of PPI-NR EoE

https://doi.org/10.14309/ctg.0000000000000540

#BrighamGI #BWHMotility

Overlapping Transcriptional Profile in Proton Pump... : Clinical and Translational Gastroenterology

String and a custom panel of EoE-specific genes. The top upregulated and downregulated genes with ≥2-fold difference in expression and statistically significant (P < 0.05) were identified. RESULTS: Nearly all the top upregulated (17 of 20) and downregulated (5 of 5) genes in EoE, compared with healthy controls, were shared between the PPI-R and PPI-NR groups. DISCUSSION: Esophageal mucosal transcript expressions are remarkably similar in PPI-R EoE and PPI-NR EoE compared with healthy controls....

LWW