Eosinophilic Esophagitis (EoE): Lessons Learned from Medicaid and the UVA EoE Cohort
https://www.youtube.com/live/wt4gW_asI7g?si=m-jNljWnzwM5FH9X
presentation by Dr Emily McGowan at Fralin Biomedical Research Institute, Feb 9, 2024
- EoE incidence increasing [18:28]
- EoE is induced in mouse model with SDS, a detergent used in toothpaste. [21:28]
- even when eosinophils are cleared with anti-IL-5 Ab, symptoms remain [29:00]
comment: I & many others with MCAS have dysphagia. If eosinophils are at the party, it is usually b/c mast cells invited them. Also, MCAS affects women more.
- they usually take more than 5 biopsy samples when trying to diagnose EoE [16:10]
- EoE is IgG4 mediated [44:26]
- EoE associated with high socioeconomic status; Dr McGowan suspects this is due to underdiagnosis in ppl w/ less access to care.
comment: it would be interesting to know of EoE is associated with high PFAS burden, which is higher in ppl w/ higher income. PFAS have surfactant properties, like SDS. Also, there's increasing use of powerful surfactants in herbicides due to development of herbicide resistance.
- the Cytosponge for minimally invasive diagnostic testing [37:56]
#Allergy #Immunology #Gastroeneterology #EosinophilicEsophagitis #Eosinophils #MastCells #MCAS #dysphagia