Show threadHannah R BridgesJan 26, 2023
1. The main #BIGUANIDE inhibitory site is identified by density in the quinone-binding channel and we can now explain how the positive charge on biguanides lends them a unique binding preference to deactive/slack-like states known to form during oxygen starvation.
Hannah R BridgesNov 19, 2022

#introduction I'm an Investigator Scientist at the MRC Mitochondrial Biology Unit at #CambridgeUniversity. I use #Structuralbiology and #Biochemistry to study respiratory complex I, using a range of techniques including single particle #CryoEM #Enzymekinetics and #Respirometry. In this role I am particularly interested in #Biguanide therapeutics, #Mitochondria, and workplace wellbeing.

I'm not just a scientist though, I like drawing and painting, and my favourite band is #Tool :)