Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial | Infectious Diseases | JAMA Internal Medicine | JAMA Network https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2838335

“Question  Is regular application of azelastine nasal spray associated with reduced risk of SARS-CoV-2 infections?

Findings  In this randomized placebo-controlled clinical trial that included 450 participants, the incidence of laboratory-confirmed SARS-CoV-2 infections was significantly lower with application of azelastine nasal spray compared with placebo treatment.
Meaning  The use of azelastine nasal spray may help to reduce the risk of SARS-CoV-2 infections.”
#JAMA #azelastine #covid

Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections

This randomized clinical trial evaluates the efficacy of azelastine as a preexposure prophylaxis against SARS-CoV-2 and other respiratory pathogens.

does azelastine nasal spray prevent COVID-19?

Unfortunately, probably not.

mathissweet
Allergy Nasal Spray Kills Cold and CoVid Viruses. Azelastine nasal spray, branded Astepro, can reduce your chances of developing a CoVid infection by a factor of 3 and cuts your cold risk by a factor of 3.5. #azelastine #astepro #allergy #CoVid #rhinovirus #commoncold
https://www.instagram.com/p/DOwe9yfDnI2/
Howard G. Smith MD, AM on Instagram: "Allergy Nasal Spray Kills Cold and CoVid Viruses Azelastine nasal spray, marketed as Astepro but also available as a generic, can reduce your chances of developing a CoVid infection by a factor of 3 and cut your chances of developing a common cold by a factor of 3.5. German researchers at Saarland University recently published their double-blind, placebo-controlled study of 450 participants in the JAMA Internal Medicine Journal. Half the subjects received azelastine 0.1% nasal spray three times a day for 56 days. The control subjects used a similarly-appearing but inactive nasal spray. Respiratory infections were confirmed using PCR analyses. The results showed that only 2.2% of the azelestine sprayers developed CoVid compared with 6.7% of controls. Only 1.8% of azelestine sprayers developed rhinovirus infections compared with 6.3% of controls. Generic azelastine spray is a prescription medication. Astepro Spray, the same medication, is available over-the-counter. If you think you might benefit, give it a try. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2838335 #azelastine #astepro #allergy #CoVid #rhinovirus #commoncold"

Azelastine nasal spray, a prescription medication, has been found to reduce the risk of developing CoVid and common cold by a factor of 3. A study published in JAMA Internal Medicine, conducted by researchers at Saarland University, found that participants who used the nasal spray had a significantly lower risk of developing respiratory infections compared to those who did not use the spray.

Instagram

'Onderzoek wijst uit: met deze neusspray heb je drie keer minder kans op corona'

"Specifiek gaat het om een spray met als actief bestanddeel ‘azelastine’. Dat is een vrij te verkrijgen geneesmiddel dat al jaren gebruikt wordt voor de behandeling van hooikoorts"

"niet alleen interessant is voor de behandeling van een besmetting maar ook voor het voorkomen ervan"

"Op vlak van bijwerkingen zagen de wetenschappers exact wat zij verwacht hadden voor dit geneesmiddel. De bekende vermoeidheid (3,1 procent), neusbloedingen (6,6 procent) en bittere smaak (9,3 procent)"

"Onderzoek testte neusspray met azelastine (geneesmiddel tegen hooikoorts) voor bescherming tegen coronavirus.
450 mensen tussen de 18 en 65 jaar namen deel, 227 van hen spoten 56 dagen lang 3x per dag de spray in hun neus.
Bij deze mensen zag men 3x minder besmettingen met het coronavirus in vergelijking met de controlegroep.
Ook het aantal luchtweginfecties met andere ziekteverwekkers was lager (tien procent versus ongeveer twintig procent).
Personen met de azelastine neusspray waren ook minder lang ziek."

"Deze neusspray zou daarom een toegankelijk middel zijn dat als aanvulling kan gebruikt worden op bestaande beschermende maatregelen zoals bijvoorbeeld een mondkapje"

https://www.margriet.nl/gezondheid/onderzoek-wijst-uit-met-deze-neusspray-heb-je-drie-keer-minder-kans-op-corona~b6bcf473/

https://archive.ph/wrilk

#gezondheid #azelastine #Covid #preventie #hooikoorts

Onderzoek wijst uit: met deze neusspray heb je drie keer minder kans op corona

Wist je dat een eenvoudige neusspray je deze herfst en winter misschien wel kan beschermen tegen het coronavirus? Duitse onderzoekers van Saarland University publiceerden hierover een nieuwe studie in ‘JAMA Internal Medicine’. De spray bleek ook effectief tegen andere virussen.

Margriet

#Astepro #azelastine #Covid
Daily squirts of a safe, over-the-counter allergy nasal spray may prevent COVID-19 infections from taking hold, according to results published Tuesday in JAMA Internal Medicine.

OTC nasal spray seemed to cut COVID infections by 67% in mid-sized trial

"The Phase 2 trial is not definitive, but it comes as vaccine access is severely restricted."
https://arstechnica.com/health/2025/09/otc-nasal-spray-seemed-to-cut-covid-infections-by-67-in-mid-sized-trial/

OTC nasal spray seemed to cut COVID infections by 67% in mid-sized trial

The Phase 2 trial is not definitive, but it comes as vaccine access is severely restricted.

Ars Technica

They’re putting this out again about azelastine & now I am worried people will buy it all up as ragweed season is approaching. FML

The over-the-counter version sucks compared to the prescription version. I cried when I bought the last bottles I could find.

Covid infection may be prevented with a common nasal antihistamine spray, trial shows https://www.nbcnews.com/health/health-news/covid-infection-may-prevented-common-nasal-antihistamine-spray-trial-s-rcna228500

#azelastine #covid

Covid infection may be prevented with a common nasal antihistamine spray, trial shows

The over-the-counter antihistamine works against a range of respiratory infections, including Covid, flu and RSV, according to researchers.

NBC News
#Azelastine Nasal #Spray for #Prevention of #SARS-CoV-2 Infections A Phase 2 #RCT

Wowza. Study out in 2020, haven't heard a thing about it. Over the counter Benadryl but taken in larger amounts, or prescription nasal spray antihistamine Azelastine taken in smaller doses, each showed antiviral activity against COVID.
#antiviral #COVID #killer #antihistamine #over the #counter #could #help #prevent #infection #study #shows #potential #Benadryl #azelastine #hydroxizine #Atarax #drugs #nasal #spray #SarsCovid2 #prevention #infect #respiratory #illness https://ufhealth.org/news/2020/existing-antihistamine-drugs-show-effectiveness-against-covid-19-virus-cell-testing
Existing antihistamine drugs show effectiveness against COVID-19 virus in cell testing - UF Health

Three common antihistamine medications have been found in preliminary tests to inhibit infection of cells by the coronavirus that causes COVID-19, University…