Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial | Infectious Diseases | JAMA Internal Medicine | JAMA Network https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2838335

“Question  Is regular application of azelastine nasal spray associated with reduced risk of SARS-CoV-2 infections?

Findings  In this randomized placebo-controlled clinical trial that included 450 participants, the incidence of laboratory-confirmed SARS-CoV-2 infections was significantly lower with application of azelastine nasal spray compared with placebo treatment.
Meaning  The use of azelastine nasal spray may help to reduce the risk of SARS-CoV-2 infections.”
#JAMA #azelastine #covid

Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections

This randomized clinical trial evaluates the efficacy of azelastine as a preexposure prophylaxis against SARS-CoV-2 and other respiratory pathogens.

does azelastine nasal spray prevent COVID-19?

Unfortunately, probably not.

mathissweet
Allergy Nasal Spray Kills Cold and CoVid Viruses. Azelastine nasal spray, branded Astepro, can reduce your chances of developing a CoVid infection by a factor of 3 and cuts your cold risk by a factor of 3.5. #azelastine #astepro #allergy #CoVid #rhinovirus #commoncold
https://www.instagram.com/p/DOwe9yfDnI2/
Howard G. Smith MD, AM on Instagram: "Allergy Nasal Spray Kills Cold and CoVid Viruses Azelastine nasal spray, marketed as Astepro but also available as a generic, can reduce your chances of developing a CoVid infection by a factor of 3 and cut your chances of developing a common cold by a factor of 3.5. German researchers at Saarland University recently published their double-blind, placebo-controlled study of 450 participants in the JAMA Internal Medicine Journal. Half the subjects received azelastine 0.1% nasal spray three times a day for 56 days. The control subjects used a similarly-appearing but inactive nasal spray. Respiratory infections were confirmed using PCR analyses. The results showed that only 2.2% of the azelestine sprayers developed CoVid compared with 6.7% of controls. Only 1.8% of azelestine sprayers developed rhinovirus infections compared with 6.3% of controls. Generic azelastine spray is a prescription medication. Astepro Spray, the same medication, is available over-the-counter. If you think you might benefit, give it a try. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2838335 #azelastine #astepro #allergy #CoVid #rhinovirus #commoncold"

Azelastine nasal spray, a prescription medication, has been found to reduce the risk of developing CoVid and common cold by a factor of 3. A study published in JAMA Internal Medicine, conducted by researchers at Saarland University, found that participants who used the nasal spray had a significantly lower risk of developing respiratory infections compared to those who did not use the spray.

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#Astepro #azelastine #Covid
Daily squirts of a safe, over-the-counter allergy nasal spray may prevent COVID-19 infections from taking hold, according to results published Tuesday in JAMA Internal Medicine.

OTC nasal spray seemed to cut COVID infections by 67% in mid-sized trial

"The Phase 2 trial is not definitive, but it comes as vaccine access is severely restricted."
https://arstechnica.com/health/2025/09/otc-nasal-spray-seemed-to-cut-covid-infections-by-67-in-mid-sized-trial/

OTC nasal spray seemed to cut COVID infections by 67% in mid-sized trial

The Phase 2 trial is not definitive, but it comes as vaccine access is severely restricted.

Ars Technica

They’re putting this out again about azelastine & now I am worried people will buy it all up as ragweed season is approaching. FML

The over-the-counter version sucks compared to the prescription version. I cried when I bought the last bottles I could find.

Covid infection may be prevented with a common nasal antihistamine spray, trial shows https://www.nbcnews.com/health/health-news/covid-infection-may-prevented-common-nasal-antihistamine-spray-trial-s-rcna228500

#azelastine #covid

Covid infection may be prevented with a common nasal antihistamine spray, trial shows

The over-the-counter antihistamine works against a range of respiratory infections, including Covid, flu and RSV, according to researchers.

NBC News
#Azelastine Nasal #Spray for #Prevention of #SARS-CoV-2 Infections A Phase 2 #RCT

Wowza. Study out in 2020, haven't heard a thing about it. Over the counter Benadryl but taken in larger amounts, or prescription nasal spray antihistamine Azelastine taken in smaller doses, each showed antiviral activity against COVID.
#antiviral #COVID #killer #antihistamine #over the #counter #could #help #prevent #infection #study #shows #potential #Benadryl #azelastine #hydroxizine #Atarax #drugs #nasal #spray #SarsCovid2 #prevention #infect #respiratory #illness https://ufhealth.org/news/2020/existing-antihistamine-drugs-show-effectiveness-against-covid-19-virus-cell-testing
Existing antihistamine drugs show effectiveness against COVID-19 virus in cell testing - UF Health

Three common antihistamine medications have been found in preliminary tests to inhibit infection of cells by the coronavirus that causes COVID-19, University…