Within tumors in the human body, there are #immune #cells ( #macrophages ) capable of fighting cancer,
but they have been unable to perform their roles properly due to suppression by the tumor.

KAIST researchers have overcome this limitation by developing a new therapeutic approach that directly ⚠️converts immune cells inside tumors into anticancer cell therapies.

KAIST President Kwang Hyung Lee announced on the 30th that a research team led by Professor Ji-Ho Park of the Department of Bio and Brain Engineering has developed a therapy in which,
when a drug is injected directly into a tumor, macrophages already present in the body absorb it, produce CAR
(a #cancer-#recognizing device) proteins on their own...
and are converted into anticancer immune cells known as "#CAR-#macrophages."

❌Solid tumors—such as gastric, lung, and liver cancers—grow as dense masses, making it difficult for immune cells to infiltrate tumors or maintain their function.

As a result, the effectiveness of existing immune cell therapies has been limited.

✅ CAR-macrophages,
which have recently attracted attention as a next-generation immunotherapy,
have the advantage of directly engulfing cancer cells while simultaneously activating surrounding immune cells to amplify anticancer responses.

⛔️However, conventional CAR-macrophage therapies require immune cells to be extracted from a patient's blood, followed by cell culture and genetic modification.

This process is time-consuming, costly, and has limited feasibility for
real-world patient applications.

To address this challenge, the research team focused on "#tumor-#associated #macrophages" that are already accumulated around tumors.

⭐️They developed a strategy to directly reprogram immune cells in the body by loading lipid nanoparticles
—designed to be readily absorbed by macrophages
—with both mRNA encoding
cancer-recognition information
and an immunostimulant that activates immune responses.

In other words, in this study,
CAR-macrophages were created by
👉"directly converting the body's own macrophages into anticancer cell therapies inside the body."
https://www.news-medical.net/news/20260102/New-therapeutic-approach-converts-immune-cells-inside-tumors-into-anticancer-cell-therapies.aspx

The dark web is one of the most mysterious and misunderstood corners of the internet. Often associated with illegal activities, it is also home to legitimate uses, such as protecting free speech and securing sensitive communications. As businesses and individuals become more digitally...

https://medium.com/@mrsno1special/the-dark-web-exposed-what-it-is-and-why-it-matters-d97f29b51117

# #mysterious #misunderstood #corners #associated #illegal

The dark web is often associated with illicit activities, cybercrime, and underground marketplaces, but it also serves as a critical space for whistleblowers, privacy advocates, and journalists. Despite its legitimate uses, the dark web has become a breeding ground for hackers, data...

https://medium.com/@mrsno1special/the-dark-web-and-cybersecurity-how-criminals-exploit-the-hidden-internet-15ba15db6d1b

# #associated #illicit #underground #serves #critical

U.S. judge restores AP’s White House access amid ongoing lawsuit #US News #Associated Press #Trump #Trump White House

https://globalnews.ca/news/11122135/ap-trump-judge-restores-white-house-press-access-lawsuit//612

Via the #Associated Press @ 2:49pm ET, Mar 15, 2025

Tens of thousands of #Italians joined a pro-Europe rally in #Rome’s city center Saturday, waving blue #EuropeanUnion flags in a sign of support & unity as a #European push for #rearmament divides the country
...

The initiative was born in response to US President #Trump’s destabilizing policies, which created an unprecedented rift between Europe & the US, strained over the war in #Ukraine & an ongoing tariff battle

https://apnews.com/article/italy-europe-rally-rome-rearm-defense-e14c1e3df35d9c328bb23644bd3adb75