Sirtuins = cellular longevity switches 🧬

These NAD+-dependent proteins:

✅ Repair DNA damage

✅ Boost mitochondrial health

✅ Regulate metabolism

✅ Enhance stress resistance

SIRT1-7 family = evolutionarily conserved across species

Key interventions:

→ NAD+ precursors (NR/NMN)

→ Caloric restriction

→ Small molecule activators

The challenge? Moving from mouse models to validated human therapeutics.

#Longevity #AgingScience #Sirtuins