Alice FrolovApr 3

Sirtuins = cellular longevity switches 🧬

These NAD+-dependent proteins:

✅ Repair DNA damage

✅ Boost mitochondrial health

✅ Regulate metabolism

✅ Enhance stress resistance

SIRT1-7 family = evolutionarily conserved across species

Key interventions:

→ NAD+ precursors (NR/NMN)

→ Caloric restriction

→ Small molecule activators

The challenge? Moving from mouse models to validated human therapeutics.

#Longevity #AgingScience #Sirtuins

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Hacker NewsSep 30, 2025

People may age faster if their dad smoked during puberty

https://www.ersnet.org/news-and-features/news/people-may-age-faster-if-their-dad-smoked-during-puberty/

#HackerNews #PeopleMayAgeFaster #DadSmoked #Puberty #HealthEffects #SmokingResearch #AgingScience

People may age faster if their dad smoked during puberty

People whose fathers smoked during puberty seem to age faster than expected, according to research presented at the European Respiratory Society (ERS) Congress in Amsterdam, the Netherlands.

ERS - European Respiratory Society