Free PhD:

Give a mouse semaglutide, measure GLT-1 trafficking in corticostriatal astrocytes specifically, and show that the transporter redistribution is what causes the behavioral change

Materials:

(1) chronic semaglutide administration in a rodent model of compulsive behavior,
(2) single-particle tracking or FRAP to measure GLT-1 surface mobility and cluster dynamics specifically in corticostriatal astrocytes
(3) extracellular glutamate microdialysis in the same animals during behavioral challenge
(4) astrocyte-specific GLT-1 conditional knockdown as a control arm to show the behavioral rescue depends on transporter redistribution and not a parallel pathway.

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