Eric Pyrrhus
Michael GerthWolbachia conference registration just opened!
https://twitter.com/yuval_gottlieb/status/1604746804771397635?s=20&t=eK_1nnOULppb7sjp7B0KDw
Jason Rasgon
- 405 Followers
- 338 Following
- 11 Posts
Mosquitoes and other crap. Huck Chair of Disease Epidemiology and Biotechnology. My posts do not represent my employer. I have no idea what i'm doing here
...And here's the flip-side of the virus-autophagy dance:
A new preprint from @vectorgen and colleagues describes how they engineered Sindbis Virus to include an #autophagy inducer and then infected mosquitos with this engineered #virus.
The resultant increase in autophagy reduced replication of the virus in mosquito.
"Sindbis virus is suppressed in the yellow fever mosquito Aedes aegypti by ATG-6/Beclin-1 mediated activation of autophagy"
https://www.biorxiv.org/content/10.1101/2023.02.02.526867v1
#virology
New work from the RasgonLab! Anopheles transmit arboviruses!
Anopheles albimanus is a Potential Alphavirus Vector in the Americas
Despite its ecological flexibility and geographical co-occurrence with human pathogens, little is known about the ability of Anopheles albimanus to transmit arboviruses. To address this gap, we challenged An. albimanus females with four alphaviruses and one flavivirus and monitored the progression of infections. We found this species is an efficient vector of the alphaviruses Mayaro virus, O’nyong-nyong virus, and Sindbis virus, although the latter two do not currently exist in its habitat range. An. albimanus was able to become infected with Chikungunya virus, but virus dissemination was rare (indicating the presence of a midgut escape barrier), and no mosquito transmitted. Mayaro virus rapidly established disseminated infections in An. albimanus females and was detected in the saliva of a substantial proportion of infected mosquitoes. Consistent with previous work in other anophelines, we find that An. albimanus is refractory to infection with flaviviruses, a phenotype that did not depend on midgut-specific barriers. Our work demonstrates that An. albimanus may be a vector of neglected emerging human pathogens and adds to recent evidence that anophelines are competent vectors for diverse arboviruses.
Happy to present our new work on Culex tarsalis microRNAs! By
@SultanAsadGhour @sujitpujhari @EbelLaboratory @ClaudiaRuecker and Ahmed Mehdi!
Happy Turkey Day to my Mastodon peeps
How do I shitpost here?
How dafuq does this work?