Patrick Martin

48 Followers
144 Following
28 Posts

Science, World Building and Story telling. Always strive to contribute to others.

Research Data Scientist at Cedars-Sinai, Los Angeles

twitter@pcnmartin
GitHubhttps://github.com/patrickCNMartin
LinkedInhttps://www.linkedin.com/in/patrick-martin-92511094/

Often working at the intersection of AI and Biology, I have developed a love-hate relationship with AI.

In this essay, I share some thoughts on the modern AI ecosystem. It’s not all doom and gloom but there is room for improvement.

https://pcnmartin.substack.com/p/a-love-hate-letter-to-ai

Vesalius 2.0 is in ‪‪Nat. Comms. !

We show how using spatial context improves cell-to-cell mapping across heterogenous spatial samples.

Thanks to the reviewers, editors, and collaborators for making this possible.

GitHub: https://github.com/WonLab-CS/Vesalius
Paper: https://www.nature.com/articles/s41467-025-62782-y

GitHub - WonLab-CS/Vesalius: Vesalius: Dissecting Tissue Anatomy from Spatial Transcriptomic Data

Vesalius: Dissecting Tissue Anatomy from Spatial Transcriptomic Data - WonLab-CS/Vesalius

GitHub

The Institute - Chapter II: Tipping Points.

A discussion on systems, complexity, and tipping points.

https://open.substack.com/pub/pcnmartin/p/tipping-points?r=2k3tin&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Tipping Points

The Institute - Chapter II

Getting structurally homogenous spatial samples is often challenging.

We developed a method to map the spatial context of cells between heterogenous samples gaining insights into development and patient sub-populations!

#SpatialBiology #scRNA #compbio

https://www.biorxiv.org/content/10.1101/2024.08.31.610638v1

I might as well have make a pinned post.

We published Vesalius a tool that uses Image analysis methods to analyze spatial-omics data.

A new version will be coming soon that will include multimodal analysis and alignment!

GitHub: https://patrickcnmartin.github.io/Vesalius/

MSB: https://www.embopress.org/doi/full/10.15252/msb.202211080

#SpatialTranscriptomics #ImageAnalysis

Vesalius

Spatial Transcriptomic Analysis using Image Analysis

Introducing The Institute: A fictional research institute which explores things I find interesting in the fields of philosophy, society, and science. Mainly science.

Chapter I: Reorganize the social network.

https://open.substack.com/pub/pcnmartin/p/reorganize-the-social-network?r=2k3tin&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Reorganize the social network.

The Institute - Chapter I

Introducing The Institute: A fictional research institute which explores things I find interesting in the fields of philosophy, society, and science. Mainly science.

Chapter I: Reorganize the social network.

https://open.substack.com/pub/pcnmartin/p/reorganize-the-social-network?r=2k3tin&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Reorganize the social network.

The Institute - Chapter I

@researchbuzz

An interesting read and initiative!

@JMarkOckerbloom

Yes - preprint are very common in my field but they come with their own set of challenges. They often serves as ways to say: I was here first! A lot of papers come half baked.

I guess that the challenge is providing a better alternative in practice rather than just a "good idea".

I will at least contribute to wikipedia summary pages.

@JMarkOckerbloom

What are your thoughts as to why they haven't taken off?