Mastodawn

CellComM Lab Jan 23, 2024

CellComM Lab Jan 18, 2024

For #CellMigration lovers
How do cells decide when facing a symmetric junction?
The membrane oscillates exploring both directions until one arm wins.
TLDR: this depends on the actin cytoskeleton & cancer cells decide faster than healthy cells
#scicomm @pj_saez
Full https://www.nature.com/articles/s41567-023-02335-6

Emergent seesaw oscillations during cellular directional decision-making - Nature Physics

Cell motion along linear confinements is deterministic. Now a model predicts deterministic oscillations in cellular polarization at a Y junction in a set-up with adhesive patterns.

Nature

CellComM Lab Jan 18, 2024

For #CellMigration lovers
How do cells decide when facing a symmetric junction?
The membrane oscillates exploring both directions until one arm wins.
TLDR: this depends on the actin cytoskeleton & cancer cells decide faster than healthy cells
#scicomm @pj_saez
Full https://www.nature.com/articles/s41567-023-02335-6

Emergent seesaw oscillations during cellular directional decision-making - Nature Physics

Cell motion along linear confinements is deterministic. Now a model predicts deterministic oscillations in cellular polarization at a Y junction in a set-up with adhesive patterns.

Nature

CellComM Lab May 4, 2023

RT @pj_saez
#MayThe4th & #CellMigration

#DarthVader cell using the force to choke another one (arrow/red nucleus) until...well, wait for it to see it in slow motion
Only the sound is missing to be like #StarWars

#scicomm @cellcommlab @focalplane_jcs #MayThe4thBeWithYou #cell

CellComM Lab May 1, 2023

RT @pj_saez
For the long weekend.

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach every corner.

All recorded under the microscope by @KuxJohan & @Marie_Adler23 @cellcommlab

#scicomm #microscopy @focalplane_jcs @Mito_News @MitoAging

CellComM Lab Apr 29, 2023

RT @pj_saez
Last week @Martina_Alamo_R finished her internship @ the @cellcommlab, and left Hamburg.
Now she is back home @LabYuseff 🇨🇱 to finish her #PhD thesis.
Good luck Marti, we already miss you (and your experiments of 300 coverslips 😅 support pic 👇🏼)

CellComM Lab Apr 14, 2023

RT @pj_saez
#ExSRRF, a new pipeline that allows to reach 25 nm resolution using widefield #microscopy
(useful for #cellbio, #ER_literature, clinics & more)

Tks for the invitation, @PuellesVictor, happy that @cellcommlab we could help you w this neat work

@NatureNano https://www.nature.com/articles/s41565-023-01328-z

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens - Nature Nanotechnology

Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

Nature

CellComM Lab Apr 12, 2023

Expansion microscopy + SRFF = #ExSRFF
low cost super resolution microscopy
https://www.nature.com/articles/s41565-023-01328-z

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens - Nature Nanotechnology

Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

Nature

CellComM Lab Apr 3, 2023

RT @robinsall
A short thread about Adam Dowdell's excellent chemotaxis paper, just out in @CurrentBiology. It shows how combinations of ligands for the same receptors cause fascinating & counterintuitive outcomes (1/n)
https://www.cell.com/current-biology/fulltext/S0960-9822(23)00294-4

Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis

Competition between different ligands for the same receptor type can explain how cells can drive negative chemotaxis in which cells migrate away from a chemical repellent. Dowdell et al. show that ligand competition and breakdown can combine to cause counterintuitive behaviors, such as two attractants combining to repel cells.

Current Biology

CellComM Lab Apr 2, 2023

RT @pj_saez
Hot from the press @CurrentBiology

Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis, by A Dowdell, et al @robinsall lab.

Great story for #CellMigration lovers

Full: https://www.cell.com/current-biology/fulltext/S0960-9822(23)00294-4 #scicomm

Competition between chemoattractants causes unexpected complexity and can explain negative chemotaxis

Competition between different ligands for the same receptor type can explain how cells can drive negative chemotaxis in which cells migrate away from a chemical repellent. Dowdell et al. show that ligand competition and breakdown can combine to cause counterintuitive behaviors, such as two attractants combining to repel cells.

Current Biology

CellComM Lab Mar 24, 2023

Here we are again accumulating celebrations
@cellcommlab
Kudos to @Marie_Adler23 for finishing your MSc !
All the hard work paid out and you got a beautiful thesis.

#SciWin #CellMigration #WomenInStem

CellComM Lab	https://www.uke.de/kliniken-institute/institute/biochemie-und-molekulare-zellbiologie/forschung/arbeitsgruppen/cell-communication-and-migration-laboratory.html
Google Scholar	https://scholar.google.com/citations?hl=en&user=MUYzeuAAAAAJ