Pictures of AMPA receptors at synapses from Axel Brunger's lab. By averaging a lot of tomogram images, they could discern scaffolding molecules bound to the complexes.

These in situ images are lower resolution than purified protein, but retain the native organization and place the receptors somewhat at the side of vesicular docking sites.

https://www.biorxiv.org/content/10.1101/2024.10.19.619226v2

#synapses #neuroscience #CellularStructuralBiology #Receptors

Not exactly news, but the Allen Brain Atlas is amazing. Finding some random protein, trawling through Pubmed for papers, but a few clicks now I know it is in the mouse Cerebellum.

For the mouse brain map. their Mac application requires OSX 10.6.8 (!!!) and crashes quite readily so the Web is probably better....

https://mouse.brain-map.org

#neuroscience #biophysics #physiology

🚨 Just a few days to go - the course is filling up, please send in your application before 30th June for full consideration!🚨

The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this September 9 - 13th. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!

More details:
https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course

#biophysics #ionchannels #physiology #TIRF

When the long side is shorter than the short side...

#DINA0

The 2nd edition of the Berlin Single Molecule Biophysics Course will be held this september. We will charge a fee for external participants but waivers and bursaries should be available if needed. Please retoot!

#biophysics #ionchannels #physiology #TIRF

https://www.biologie.hu-berlin.de/en/groupsites/cellbp/berlin-smb-course

Hmmm, I think #Slack just crossed a line into M$/LinkedIn territory. Careful my friends, this is the way to the dark side.

"You cannot join this workspace with a hidden email. Try again with a different email address; we suggest the one you use for work."

Very interesting structures of the GluN1/N3 variant NMDA receptor from Michalski and Furukawa. Unprecedented 80º rotation of the GluN3 subunit into a desensitised conformation, which could be disrupted by mutation.

#biophysics #receptors #neuroscience

https://www.science.org/doi/pdf/10.1126/sciadv.adl5952

Cryo-ET of the SC-CA1 hippocampal connection from Eric Gouaux group. Nice confirmation that GluA2 N-terminus is closer to the pre-synapse than to the post-synapse!

#synapse #neuroscience #AMPAReceptor

https://www.biorxiv.org/content/10.1101/2024.04.01.587595v1.full.pdf