Mastodawn

Andy Truman PhD Sep 8, 2023

A really important skill for trainees to learn is to be a “closer” of a project-that is to take it over the finish line for publication. This means doing the experiments, getting the figures/text ready for submission and being prepared to do review corrections 😀

Andy Truman PhD Jun 15, 2023

Excited to share our latest Forum article in Trends in Biochemical Sciences “Understanding chaperone specificity: evidence for a ‘client code’” https://www.sciencedirect.com/science/article/abs/pii/S0968000423001329?dgcid=author

Andy Truman PhD Dec 18, 2022

Remembering the first and only time I made science themed cookies 😀 #cookies #dnagel #science

Andy Truman PhD Dec 4, 2022

Chaperone code m&m’s ready to give out at #CellBio2022 😀 #chaperone #hsp70 #science

Andy Truman PhD Nov 21, 2022

Proteomic studies have uncovered a huge number of post-translational modifications on chaperones (over 100!). We like to think of these #PTMs like keys on a piano. Stresses to cells like heat or DNA damage cause a unique combination of keys (PTMs) to be played making a song (unique #Hsp70 function). We are trying to match stresses to each PTM and work out the function of this "chaperone code" in normal and cancerous cells. For more, please see: https://www.sciencedirect.com/science/article/pii/S0021925817501076?via%3Dihub

Andy Truman PhD Nov 21, 2022

#Introduction: I am an Associate Professor at UNC Charlotte studying the connection between #protein folding and disease.

When proteins are made in the cell, they come out as a string of amino acids. To function in the cell, this string needs to fold into a complex 3D shape. Many of our proteins need help to fold correctly. This is where molecular #chaperones come in. These proteins work as custodians of the cell by folding proteins. We work on the Hsp70 chaperone in yeast and cancer cells.