Computational + Molecular Genetics
Donnelly Centre @ UofT
| Scientist | Occasionally |
| Climber | Trying |
| Coffee burner | Always |

| Scientist | Occasionally |
| Climber | Trying |
| Coffee burner | Always |
Whoops, here it is: https://www.nature.com/articles/s41467-023-38301-2
RNA viruses are defined by linear RNA genomes encoding an RNA-dependent RNA polymerase, while viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode self-cleaving catalytic RNAs. Here, the authors identify over 20,000 candidate viroid-like elements, and show that infectious agents of fungi display hybrid features of viroid-like RNAs and RNA viruses.
"What is a virus?"
The answer to this old question is going to change in b/c of studies like this. Here we discover +20,000 viroid-like agents & show exp. proof for 2 independent lineages of Viroid:RNA virus hybrids, linking these kingdoms of infectious agents.
Paper Link: https://nature.com/articles/s4146
Marcos tw-thread: https://twitter.com/Marcos_dlP/status/1654459198187470849
Galbut virus (family <i>Partitiviridae</i>) infects <i>Drosophila melanogaster</i> and can be transmitted vertically from infected mothers or infected fathers with near perfect efficiency. This form of super-Mendelian inheritance should drive infection to 100% prevalence, and indeed, galbut virus is …
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RT :)
@naturepoker You can also run ColabFold in a colab notebook.
https://colab.research.google.com/github/sokrypton/ColabFold/blob/main/AlphaFold2.ipynb
The metavirome of 31 tick species sheds light on the diversity and distinct evolution of tick-associated RNA viruses, and lays the foundation for better understanding of tick–virus interaction.