Michael Bachmann

43 Followers
98 Following
77 Posts

The Guardian covers the story of the mass resignation of "Neuroimage" (published by Elsevier) editorial board.

https://www.theguardian.com/science/2023/may/07/too-greedy-mass-walkout-at-global-science-journal-over-unethical-fees

#elsevier #OpenAccess #Neuroscience #ScienceMastodon

‘Too greedy’: mass walkout at global science journal over ‘unethical’ fees

Entire board resigns over actions of academic publisher whose profit margins outstrip even Google and Amazon

The Guardian

I wrote this little program to visualise biological tracking data from #microscopy. We used it a lot for sense checking and verifying a lot of our data, but sadly it won't make it into our next paper. Anyway, today I tidied it up a bit and will make it available with all the rest of the code for others to use.

#reproducibility #CellBiology #ScienceMastodon

May Issues are out from our three journals!

Cover images in @JCellBiol by Mascarau et al.: https://rupress.org/jcb/issue/222/5

@JExpMed by Qin et al.: https://rupress.org/jem/issue/220/5

@JGenPhysiol by Asencio et al.: https://rupress.org/jgp/issue/155/5

We hope you enjoy reading new issues!

Journal of Cell Biology

Read Volume 222 Issue 5 of Journal of Cell Biology.

Rockefeller University Press
@JCellBiol Can't beat a bit of SEM. What a great cover!

Poster alert! @J_Cell_Sci

🔬Genetically encoded imaging tools for investigating cell dynamics at a glance🔬

#optogenetics

https://journals.biologists.com/jcs/article-abstract/136/7/jcs260783/306976/Genetically-encoded-imaging-tools-for?redirectedFrom=fulltext

Genetically encoded imaging tools for investigating cell dynamics at a glance

Summary: Discover how to apply the latest genetically encoded imaging tools to examine the dynamic cell function that you are most interested in.

The Company of Biologists

ConFERMing the role of talin in integrin activation and mechanosignaling

In their #OpenAccess Review, @MitchBachmann, Vesa Hytönen, Jinhua Wu, Bernhard Wehrle-Haller and colleagues summarise the structural and regulatory feature of talin in adhesion & force transmission and signalling.

https://journals.biologists.com/jcs/article/136/8/jcs260576/307121/ConFERMing-the-role-of-talin-in-integrin

ConFERMing the role of talin in integrin activation and mechanosignaling

Summary: Talin is a key protein controlling integrin-dependent cell–matrix adhesions. Here, we summarize its function in linking mechanical coupling to the actin cytoskeleton and adhesion signaling.

The Company of Biologists
RT @matthewcobb
70 years ago, 3 papers appeared in @Nature under the title ‘Molecular structure of nucleic acids’. In an article in Nature today (link at end) @nccomfort and I shed new light on ‘what Watson and Crick really took from Rosalind Franklin’. This thread summarises our findings. 1/23

Happy to announce our newest review, published in @J_Cell_Sci:

https://journals.biologists.com/jcs/article/136/8/jcs260576/307121/ConFERMing-the-role-of-talin-in-integrin?searchresult=1

Starting point was our observation that the talin head domain forms a canonical FERM fold in contrast to the elongated structure observed in the past. This new structural information allows to integrate several other findings about talin and its role in integrin activation.
And if you want to get a dive into structural biology, here are cxs files to make it easier: 10.26037/yareta:eyekudd2rvab3oofli5auhoz7u

ConFERMing the role of talin in integrin activation and mechanosignaling

Summary: Talin is a key protein controlling integrin-dependent cell–matrix adhesions. Here, we summarize its function in linking mechanical coupling to the actin cytoskeleton and adhesion signaling.

The Company of Biologists

So look—I've never been quite as big a fan of Steven Wolfram as Steven Wolfram is.

But credit where due: if you can get past the idiosyncrasies, in this piece he does a better job than I could of trying to explain from the ground up what it is that ChatGPT is doing.

https://writings.stephenwolfram.com/2023/02/what-is-chatgpt-doing-and-why-does-it-work/

What Is ChatGPT Doing … and Why Does It Work?

Stephen Wolfram explores the broader picture of what's going on inside ChatGPT and why it produces meaningful text. Discusses models, training neural nets, embeddings, tokens, transformers, language syntax.

"mScarlet3: A brilliant and fast-maturing red fluorescent protein"

https://www.nature.com/articles/s41592-023-01809-y

#Microscopy #FluorescentProtein #Science #Seinfeld

mScarlet3: a brilliant and fast-maturing red fluorescent protein - Nature Methods

Two mScarlet variants with high brightness and fast maturation times have been evolved. These variants behave favorably as fusion tags and Förster resonance energy transfer acceptors.

Nature