Mastodawn

Katie Lotterhos Feb 22, 2024

I'm excited to share a new paper from my lab out now in @EvolLetters "Interpretation issues with “genomic vulnerability” arise from conceptual issues in local adaptation and maladaptation" - https://academic.oup.com/evlett/advance-article/doi/10.1093/evlett/qrae004/7603943 . This paper introduces different kinds of fitness offsets, shows that they are not equal, and discusses which to use for different conservation applications.

Interpretation issues with “genomic vulnerability” arise from conceptual issues in local adaptation and maladaptation

Abstract. As climate change causes the environment to shift away from the local optimum that populations have adapted to, fitness declines are predicted to

OUP Academic

Katie Lotterhos Jan 5, 2024

My new years gift to you all - a whole page of Biostatistics memes created by my students!
https://sites.google.com/site/katielotterhos/graphics-hall-of-fame/statistics-memes

Lotterhos Lab - Statistics Memes

Fall 2023 Biostatistics Memes, Poems, and Haikus My students get a bonus assignment to create original Statistics Media. Here are some of our favorites! Each image has the student's name in the filename. Please give the student credit if you use them!

Katie Lotterhos Nov 8, 2023

You know you have good people when it's their idea to take lab photos in front of a "nobody cares, work harder" sign 😅

Katie Lotterhos Apr 26, 2023

JUST PUBLISHED: "A second unveiling: Haplotig masking of the eastern oyster genome improves population-level inference" #Evolution #Genomics #PopGen #oyster https://onlinelibrary.wiley.com/doi/10.1111/1755-0998.13801

A haplotig in an assembly occurs when a single region is split into two places in the reference. We had them everywhere in our first eastern oyster assembly! This causes a bimodal distribution of coverage. This study shows how haplotigs affect pop gen inference and how to improve the reference by masking haplotigs.

Katie Lotterhos Mar 28, 2023

Excited to share a new Shiny App for understanding the Multivariate Breeder's Equation and the G-matrix! This app uses oyster disease and salinity tolerance as an example for understanding how multiple traits evolve in response to multiple stressors. There are cases for students to explore as well as two challenges (e.g. given the observed trait evolution, what kind of genetic architectures could have led to this pattern?).
https://lotterhos.shinyapps.io/Gmatapp/?_ga=2.105276676.644884313.1680003268-567935094.1679416129

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Katie Lotterhos Mar 15, 2023

Finally, to explore how trait clines evolve despite weird patterns at the underlying alleles, there is a complex 6-trait simulation with range expansion and secondary contact. Each trait adapts to a different environmental landscape, based on real BIOCLIM for western Canada. Even in this complex case, adapted traits can be accurately inferred from multivariate ordination when adaptive loci cannot be discovered. Check out the paper to see the video and learn more:
https://www.pnas.org/doi/full/10.1073/pnas.2220313120

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Katie Lotterhos Mar 15, 2023

This paper also highlights a 'catch 22' with structure corrections in genotype-environment associations (GEAs) - either riddled with false positives without structure correction, or decreased power with structure correction if structure correlates with the selective environment. In multivariate space, correction for structure can jumble the signal of multivariate adaptation. https://www.pnas.org/doi/full/10.1073/pnas.2220313120

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Katie Lotterhos Mar 15, 2023

This paper shows that redundancy analysis (RDA), a multivariate ordination method, cannot find the loci responsible for multivariate adaptation. However, this study shows that even when inference from genotype–environment association methods is inaccurate, multivariate quantitative traits can still be accurately estimated from genotypes and environments in an RDA. A new method is introduced to transform RDA loadings into trait predictions. https://www.pnas.org/doi/full/10.1073/pnas.2220313120

Katie Lotterhos Mar 15, 2023

Out today in PNAS: "The paradox of adaptive trait clines with nonclinal patterns in the underlying genes" https://www.pnas.org/doi/full/10.1073/pnas.2220313120 This study shows that under complex multivariate adaptation, trait clines can evolve despite nonmonotonic allele frequency patterns across environmental gradients. These patterns are not discovered by genotype–environment association methods, which are widely used to discover adaptation. #EvolutionPaper #EcoEvo #SLiM #Genetics #Genomics #EvolgenPaper #PopGen

Katie Lotterhos Mar 14, 2023

“There’s an app for that!” #Workshop

This 5-hour workshop will provide an introduction for biologists to building their own #apps for data collection. By the end of the workshop, applicants will have built their first app and will have the fundamental knowledge to build their own apps. Applicants will also learn how to best structure their data for app development. Apply: https://www.eventbrite.com/e/theres-an-app-for-that-an-introduction-for-biologists-registration-574729731097 #Ecology #Biology #Evolution #EcoEvo

There's an App for That! An introduction for biologists

This 5-hour workshop will provide an introduction for biologists to building their own apps for data collection.

Eventbrite

Lotterhos Lab Website	https://sites.google.com/site/katielotterhos/home
Evolving Seas research coordination network	https://rcn-ecs.github.io/