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Abhishek Chatterjee Dec 29, 2022

Ken Hallenbeck Dec 27, 2022

Lovely #synbio read for those of you with an interest in peptide macrocycles:

https://www.nature.com/articles/s41557-022-01082-0

The authors use an E.Coli that has been re-written to remove 3 codons from it's natural genome. Then, using those codons, they synthesize peptide macrocycles that contain non-natural amino acids.

Cool stuff :)

Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles - Nature Chemistry

Macrocyclic peptides can be genetically encoded and synthesized in cells; however, the programmable diversity is limited. Now, macrocycles containing two non-canonical amino acids have been genetically encoded and synthesized in codon-reassigned Syn61Δ3 cells. Incorporating diverse hydroxy acids in Syn61Δ3 cells enables the synthesis of non-natural depsipeptides containing either one or two ester bonds.

Nature

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Abhishek Chatterjee Dec 27, 2022

@klanglab Thank you!

Abhishek Chatterjee Dec 22, 2022

Our work on Virus-Assisted Directed Evolution of enhanced suppressor tRNAs (VADER) in mammalian cells just came out! It was a long road since we first envisioned this seven years ago. Thankful for the creativity and perseverance of an incredible team led by Delilah Jewel and Rachel Kelemen, who made this dream a reality. https://rdcu.be/c16Xk

Abhishek Chatterjee Dec 11, 2022

Anirban Mahapatra Dec 6, 2022

Work with me, an amazing team at #ASM, and leading researchers and editors at #mBio, #mSphere and mSystems in making these #OpenAccess journals indispensable to everyone interested in the microbial sciences. US-based, remote work possible.

Please share broadly.

#microbiology #MicrobiologyJobs #openscience #sciencepublishing

https://recruiting.ultipro.com/AME1097AMESO/JobBoard/20f80d94-2e8b-41f1-81bd-2808157c95e1/OpportunityDetail?opportunityId=a230dbb9-d33f-4166-b20a-34e1d60e3d92

Abhishek Chatterjee Nov 29, 2022

Rajini Rao Nov 29, 2022

Well, there is fraud in scientific publishing and then there's comedy.

This absurd figure was found in a published paper and reported on the bird app by Josemari Feliciano. It's too funny not to share here. Can you tell what is wrong?

Hint: This is NOT a "T-test" 😂

Ref: https://doi.org/10.1155/2022/3802603

#ScienceMastodon #AcademicPublishing #Science #Fraud

Monitoring of Sports Health Indicators Based on Wearable Nanobiosensors

Biosensors are instruments that are sensitive to biological substances and convert their concentration into electrical signals for detection. Generally speaking, there are two main means to promote health: one is medical intervention, and the other is exercise intervention. Medicine is mainly the second half of the health decay of the whole person, that is, disease treatment and control, while exercise intervention is mainly to prevent and promote the first half of the health decay. The purpose of this paper is to study the biochemical properties of nanomaterials and the exercise health of the elderly. In this paper, an electrochemical research method for detecting the kinase activity of polynucleotides by streptavidin-gold nanoparticles and enzyme amplification is proposed based on the thermophysical properties of materials and the properties of nanoparticles. The experimental results show that, compared with the traditional electrochemical method, the method has the advantages of simple operation, high sensitivity, and high selectivity, its linear range is from 0 U/mL to 5 U/mL, and the detection limit is 0.01 U/mL. In contrast, AgNWs cotton fiber films exhibited lower volume resistivity. The experimental design of this paper provides a theoretical and practical basis for researchers and has great research significance for the innovative research and development of nanomaterials.

Abhishek Chatterjee Nov 23, 2022

Nicolas Cornelissen Nov 22, 2022

We can now enzymatically generate S-adenosyl-L-methionine (SAM) analogues with modifications at the sulfonium center AND at the nucleoside. These can be used to increase the selectivity of certain #methyltransferases over others. Big thanks to Mehmet, Aileen, Ezgi and Andrea!

Abhishek Chatterjee Nov 18, 2022

Powerful strategy by Ben Cravatt + @davidrliu that combines ABPP and base editing to predict ligandability of essential cysteines in >100 cancer dependency proteins.
https://www.biorxiv.org/content/10.1101/2022.11.17.516964v1

Abhishek Chatterjee Nov 18, 2022

Soragni:Lab Nov 18, 2022

You can pin more than one toot to your profile!! That on top of the edit button.. isn’t this place glorious??
Welcome everyone who just joined over the past day 👋

#mastodon #TwitterMigration #ScienceMastodon

Abhishek Chatterjee Nov 18, 2022