StructBiolCommunicationsFeb 14, 2024
The structure of the RNA-recognition motif of fruit fly TRMT2A is highly similar to that of the human enzyme despite low sequence similarity @ActaCrystF
#RRM #TRMT2A #Methyltransferases https://doi.org/10.1107/S2053230X24000645
Crystal structure of the RNA-recognition motif of Drosophila melanogaster tRNA (uracil-5-)-methyltransferase homolog A

The 1.6 Å resolution crystal structure of the RNA-recognition motif of D. melanogaster tRNA (uracil-5-)-methyltransferase homolog A is reported.

Acta Crystallographica Section F
Cell Chemical BiologyJan 19, 2024
#Review Targeting #cap1 #RNA #methyltransferases as an #antiviral strategy by Yuta Tsukamoto, Manabu Igarashi, and Hiroki Kato at @UniBonn @HokkaidoUni @HokkaidoUnivPR https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00426-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
Cell Chemical BiologyDec 12, 2023
Online now! #Review Targeting #cap1 #RNA #methyltransferases as an #antiviral strategy by Yuta Tsukamoto, Manabu Igarashi, and Hiroki Kato at @UniBonn @HokkaidoUni @HokkaidoUnivPR https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(23)00426-9?rss=yes&utm_source=dlvr.it&utm_medium=mastodon #chembiol
Nicolas CornelissenNov 22, 2022
We can now enzymatically generate S-adenosyl-L-methionine (SAM) analogues with modifications at the sulfonium center AND at the nucleoside. These can be used to increase the selectivity of certain #methyltransferases over others. Big thanks to Mehmet, Aileen, Ezgi and Andrea!