Safety Warning for people on Rapamycin / Sirolimus / Rapamune

Chrysanthemum, Dandelion, Bishop's Weed, and/or Liquoirce, even if blended with other tea ingredients, can interact with the medications, including stopping absorption & be potentially dangerous. Please be careful.

For me personally, chrysanthemum tea blocked the efficacy of my latest dose of rapamycin. I'm really hoping that's all that it did.

https://pubmed.ncbi.nlm.nih.gov/24824478/

#LongCovid #MECFS #rapamycin #sirolimus #transplant #polybio #putrinoLab #rapamune #mTorInhibitor #lymphaticMalformation #TuberousSclerosisComplex

Medication Interaction Warning Edit:

Liquorice, Dandelion, Bishop’s Weed and Chrysanthemum can impact efficacy and safety of a LOT more medications.

The liver impact they have is because of the same CYP3A4 interaction is the GRAPEFRUIT WARNING. Not medical advice, but if you’ve been warned by a prescriber, pharmacist, or bottle not to have grapefruit (pomelo, bitter orange, certain other fruits), maybe don’t have those herbs until you talk to someone knowledgable.

https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions

Grapefruit–drug interactions - Wikipedia

Additional drug table about herbal tea and medication interactions

https://www.ebmconsult.com/content/pages/medications-herbs-cytochrome-p450-cyp-enzyme-inhibitors

Medication & Herbal Inhibitors of the Cytochrome P450 (CYP) Enzymes Drug Table

Evidence-Based Medicine Consult

@NyxMir oh i didn't know that about chrysanthemum!
@NyxMir GINGER!?!?!?

@ldottxt Check the absorption windows of your meds and you might be able to stagger?

Sirolimus 2x/week only needs 1 hour each dose. I think this means hypothetically I could take chrysanthemum on other days, but buspirone is also CYp3A4 and a 2x every day med so it's not reasonable for me to do that in actuality.

@NyxMir CBD likewise affects that.

@NyxMir inhibition of CYP3A4 is gonna wreak havoc on the metabolism of most meds (it's one of the main enzymes involved; inhibiting it can result in increased blood levels of most meds, which, depending on what med it is, might or might not cause issues (some meds are active by themselves, for which inhibition of CYP3A4 might increase the effect thereof, and some are prodrugs, meaning only their metabolites are active, and for those, the effect might decrease/slow down))

Depending on how much the tea inhibits CYP3A4 it might be quite dangerous combined with certain meds.

@ity yes this!! I was JUST reading it’s the GRAPEFRUIT JUICE WARNING one and I was coming back to add an addendum about how many meds they can impact. Huge yikes!!
@NyxMir Yep grapefruit juice is one of the more famous ones, to the point it has a Wikipedia section :3 https://en.wikipedia.org/wiki/Grapefruit_juice#Drug_interactions
Grapefruit juice - Wikipedia

@ity LOL I was LITERALLY just there!! Tysm