Matt WillemsenApr 2, 2024
Neurobiologists Have Discovered How Stress Turns Into Fear – And a Method To Block It
https://scitechdaily.com/neurobiologists-have-discovered-how-stress-turns-into-fear-and-a-method-to-block-it/ #psychology #Brain #Fear #Neuroscience #PTSD #Stress #neurotransmitters
Neurobiologists Have Discovered How Stress Turns Into Fear – And a Method To Block It

Neurobiologists have discovered how stress turns into fear in the brain — in conditions such as PTSD — and a method to block it. Our nervous systems are naturally wired to sense fear. Whether prompted by the eerie noises we hear alone in the dark or the approaching growl of a threatening animal, ou

SciTechDaily
Show threadRhyothemis

@mattotcha

'they injected the dorsal raphe of the mice with an adeno-associated virus (AAV)'
might be clearer if it read
'... with a modified adeno-associated virus (AAV)'
{i.e., gene therapy}

~

The journal article is paywalled, but the preprint is available:
https://doi.org/10.1101/2023.05.10.540268

" Thus, prompt fluoxetine
may block the transmitter switch in the 5-HTlwDR by blocking glucocorticoid receptor-mediated
gene transcription in 5-HTlwDR neurons. We found that treatment with fluoxetine two weeks after
footshock did not block transmitter switching and acquisition of generalized fear. The short time
window for effective therapy may explain why PTSD patients with long histories of this disorder
are less responsive to SSRIs (56)"

#fluoxetine #Prozac

Apr 2, 2024 at 1:23pmWeb