Short-term dietary changes can result in mucosal and systemic immune depression | Nature Immunology

Based on alternating on/off high fat diet in mice.

"We speculate that in order to guarantee efficient digestion of energy-dense nutrients, a transient downregulation of immunity might have been evolutionarily tolerated. However, this may have come at a price, creating windows of opportunities for pathogenic infections" #immunology #research #science #diet

https://www.nature.com/articles/s41590-023-01587-x

Short-term dietary changes can result in mucosal and systemic immune depression - Nature Immunology

Here, the authors show that short-term consumption of energy-dense diets deficient in fiber, similar to eating patterns for many people today, results in a transient depression of the mucosal and systemic immune systems such that susceptibility to bacterial infection is increased.

Nature
@feargal @gpollara It would be fascinating to know whether apart from the diet composition, the "usual suspects" of the microbiome would be linked to mucosal fitness... #immunology #microbiome
@halama_immuno @feargal excuse my ignorance, could I ask what you mean re usual suspects?
@gpollara @feargal Sorry for the brevity...I just hinted at the literature that has found bacteria with specific roles in butyrate regulation like Faecalibacterium prausnitzii relevant across different medical conditions...
https://pubmed.ncbi.nlm.nih.gov/36758522/
Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS - PubMed

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by unexplained debilitating fatigue, cognitive dysfunction, gastrointestinal disturbances, and orthostatic intolerance. Here, we report a multi-omic analysis of a geographically diverse cohort of 106 cases and 91 healthy co …

PubMed