Mastodawn

Jazmyn Oyster Jun 28, 2023

An inhaled Covid vaccine booster was more than 5-fold effective for inducing neutralizing antibodies at 28-days, and more durable at 1-year, than shots, vs Omicron BA.5 in a randomized trial
https://thelancet.com/journals/laninf/article/PIIS1473-3099(23)00350-X/fulltext

Namnezia Jun 27, 2023

@erictopol Live attenuated?

Erika Wittekind Jun 27, 2023

Nice! Bet it comes without the killer arm pain, too.

Elzi Volk Jun 30, 2023

@erikalyn @erictopol That’s highly individual, not a generalization.

Erika Wittekind Jun 30, 2023

Yes, of course, as all side effects are. I get every available shot anyway. This was just me getting excited about some promising results for an option that wouldn't involve a shot in the arm.

OldeHippi 🦋🎨🙏🌺Jun 27, 2023

Wow!!

OldAndCranky Jun 27, 2023

@erictopol stick it up my nose.

Avocado Toast Jun 28, 2023

@erictopol great how do I get one?

AnAffordableWizard Jun 28, 2023

@erictopol Might be easier to convince the hesitant to start boosting again too (though sadly nothing will convince the antivaxers. Thats a matter of faith, not reason, for them)

@erictopol What's the relationship between "inactivated" and "mRNA"?

(What I'm really interested in is: how does this sentence in the abstract relate to the US vaccine situation? "...who had received two doses of inactivated COVID-19 vaccine as their primary regimen.")

Bc Clarity Carlton-Martin Jun 28, 2023

@erictopol Not a nasal spray

quixote Jun 28, 2023

@erictopol More than 5-fold as effective at preventing infection! That's great news!

I'm glad the current vaccines stop us from dying, but, honestly, we're far from done yet. _Preventing infection_ is the goal.

Except from the standpoint of politicians who'd just like to get away from all the nasty headlines.

PixiePancake Jun 28, 2023

@erictopol Sign me up.

bzzyb Jun 28, 2023

@erictopol this sounds really good but, I hope if this comes to be we won't have to get them inside of pharmacies that have no airborne precautions

artisanrox Jun 28, 2023

This is very exciting!!! I hope it rolls out to everyone soon!

TransitBiker Jun 28, 2023

@erictopol cool. Needs to be an at-home kit.

The Great Llama

@erictopol
Fumigating fogger style delivery system when?

I'm kidding, but the thought is enticing.

Moritz HaGadoll Jun 28, 2023

@erictopol
Vac be in the air tonight... 😊

Osma A 🇫🇮🇺🇦Jun 28, 2023

For those asking whether Ad5-nCov is live or attenuated:

It's a recombinant, with a weakened adenovirus carrier mutated to exhibit the SARS-CoV-2 spike protein. The spike protein is what triggers the antibody reaction, but the virus itself isn't there. Wild adenoviruses cause flu, this one isn't strong enough for it and is used in many vaccines for the same carrier function.

More on the vaccine:
https://www.who.int/news-room/feature-stories/detail/the--cansino-biologics-ad5-ncov-s--recombinant---covid-19-vaccine--what-you-need-to-know
@erictopol

The CanSino Biologics Ad5-nCoV-S [recombinant] COVID-19 vaccine: What you need to know

The WHO Strategic Advisory Group of Experts (SAGE) on Immunization has issued Interim recommendations for use of the Moderna mRNA-1273 vaccine against COVID-19 in people aged 18 years and older.

GreySkies Jun 28, 2023

@osma @erictopol

Does this mean that the immuno-compromised can get it for instance?

fishelfe Jun 28, 2023

@erictopol
WANT!

Mz. April Daniels Jun 28, 2023

@erictopol awesome! I want the inhaled vaccine now plz

Pepper 🐾Jun 28, 2023

@erictopol check it @LaughterInLight

Paul Jun 28, 2023

@erictopol The conspiracy theorists are going to LOVE this! ;-)

Mordantivore Jun 28, 2023

@erictopol How is it for immunocompromised people?

Supportive Tree-based lifeform Jun 28, 2023

@erictopol
where do I get one of these bad boys?

True Slicky Jun 28, 2023

@erictopol Yeah, but how are they going to get the microchip in an aerosolized vaccine booster?

Martin Elliott Jul 2, 2023

When can I get some? :)

Florence Jul 5, 2023

@erictopol thanks for posting 🙂🙂