Eric TopolJun 27, 2023
An inhaled Covid vaccine booster was more than 5-fold effective for inducing neutralizing antibodies at 28-days, and more durable at 1-year, than shots, vs Omicron BA.5 in a randomized trial
https://thelancet.com/journals/laninf/article/PIIS1473-3099(23)00350-X/fulltext
Show threadOsma A 🇫🇮🇺🇦

For those asking whether Ad5-nCov is live or attenuated:

It's a recombinant, with a weakened adenovirus carrier mutated to exhibit the SARS-CoV-2 spike protein. The spike protein is what triggers the antibody reaction, but the virus itself isn't there. Wild adenoviruses cause flu, this one isn't strong enough for it and is used in many vaccines for the same carrier function.

More on the vaccine:
https://www.who.int/news-room/feature-stories/detail/the--cansino-biologics-ad5-ncov-s--recombinant---covid-19-vaccine--what-you-need-to-know
@erictopol

The CanSino Biologics Ad5-nCoV-S [recombinant] COVID-19 vaccine: What you need to know

The WHO Strategic Advisory Group of Experts (SAGE) on Immunization has issued Interim recommendations for use of the Moderna mRNA-1273 vaccine against COVID-19 in people aged 18 years and older.

Jun 28, 2023 at 6:11amWeb
Show threadGreySkiesJun 28, 2023

@osma @erictopol

Does this mean that the immuno-compromised can get it for instance?