Javier Díaz-NidoA comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Analysis of 40 common human brain diseases identifies 5 major transcriptional patterns, representing tumor-related, neurodegenerative, psychiatric and substance abuse, and 2 mixed groups of diseases affecting basal ganglia and hypothalamus.
#Neuroscience #Brain #Neurology #NeurologicalDiseases #Psychiatry #PsychiatricDiseases #MentalDiseases #NeurodegenerativeDiseases #Neurodegeneration #NeurogeneticDiseases #Neurogenetics #Transcriptome #Transcriptomics #Genomics #MolecularBiology #Biomedicine
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002058
A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Analysis of the transcription patterns of risk genes for human brain disease reveals characteristic expression signatures across brain anatomy; these can be used to compare and aggregate diseases, providing associations that often differ from conventional phenotypic classification.