#COVID19 #VariantDashboard - #USA
[without "Airport Surveillance" sequences]

Top lineages (#15DayTrends):
XBB.1.5 (65.3%)
XBB.1.9.1 (3.2%)
XBB.1.16 (2.4%)
XBB.1.5.1 (2.2%)
XBB.1.5.13 (1.5%)
XBB.1.5.17 (1.5%)
XBB.1.5.15 (1.2%)
XBB.1.9.2 (1.2%)
FL.2 (1.1%)
XBB.2.3 (1%)

2/n

Airport sequences constitute ~19% of sequences with sample collection dates in the last 15 days (#15DayTrends)

Its going to be a three way race to outcompete XBB.1.5*: XBB.1.9* vs XBB.1.16* vs XBB.2.3*

As of now, XBB.1.16* family looks to over take everything else!

3/n

Sequence count by US States

#Texas, #NewYork and #California have submitted a big share of sequences with specimen collection dates on or after 04/18/2023

XBB.1.5 is still at the top spot; followed by XBB.1.9.1 and XBB.1.16

4/n

.@CDCgov updated variant proportions estimates on 04/28/2023 (updated every Friday)

Prudent to start tracking EG.1*, XBB.1.16.1 & XBB.2.3* as well

https://twitter.com/RajlabN/status/1651967457064628228

5/n
---
RT @RajlabN
SARSCoV2 #VariantProportions - #USA |04/28/23

New @CDCgov #Nowcast estimates:

Top circulating lineages:

XBB.1.5 (68.8%) ⬇️
XBB.1.16 (11.7%) ⬆️
XBB.1.9.1 (9%)
XBB.1.9.2 (3.7%)
XBB (2.4%)
XBB.1.5.1 (2.2…
https://twitter.com/RajlabN/status/1651967457064628228

XBB.1.16 has the potential to outcompete all other circulating lineages.

Everyone is closely watching XBB.1.16 hotspots for clues

Tracker: https://public.tableau.com/app/profile/raj.rajnarayanan/viz/TrackingXBB_1_16LineageOverTime/XBB_1_16

6/n

XBB.1.16 is one of the fittest variant in circulation right now.. and is picking up additional mutations... "its the one to watch"

H/T @ErinMPrater @WellatFortune
@FortuneMagazine
https://fortune.com/well/2023/03/31/arcturus-covid-variant-watch-who-world-health-organization-xbb116-omicron-wave

7/n

Predicted Immune Escape and ACE2 binding of top lineages in USA (relative to BA.2)

Bivalent boosters (OG/Omicron.BA.5) will potentially protect the boosted from getting severe disease/ hospitalizations.

Get updated if you haven't already!
https://public.tableau.com/app/profile/raj.rajnarayanan/viz/ImmuneEscapevsACE2BindingrelativetoBA2-USA15DayTrends/Dashboard2

8/n

.@CDCgov has authorized a second dose of the bivalent Omicron-BA.5 vaccine for older adults and immunocompromised adults https://twitter.com/RajlabN/status/1648819491378192384

9/n
---
RT @RajlabN
.@CDCgov allows older adults and immunocompromised adults to get second dose of the bivalent Omicron-BA.5 vaccine https://twitter.com/CDCgov/status/1648798530767560707
https://twitter.com/RajlabN/status/1648819491378192384

#Hospital #Capacity - (by State/Division)

All hospitalizations not just COVID-19
https://public.tableau.com/app/profile/raj.rajnarayanan/viz/HospitalCapacity-USA/HospitalCapacity

10/n

#COVID19 #Hospitalizations in the #UnitedStates

>60 yr old & immunocompromised Have a good look at @CDCgov info on #Boosters!

#Ventilate Indoor spaces

Sick? --> Wear a good quality #Mask!

Hospital Tracker (by States, by age group):https://public.tableau.com/app/profile/raj.rajnarayanan/viz/COVID19HospitalizationsUSA/COVID19_HOSP_USA

11/n

Status of the latest #COVID19 Wave in #NewYork #Bellwether #State

XBB.1.5 is still the top circulating lineages in NY [includes airport surveillance seqs]

12/n

Status of the latest #COVID19 Wave in #California

XBB.1.5 is still the top circulating lineage in CA (#15DayTrends)

includes airport surveillance sequences

13/n

Status of the latest #COVID19 Wave in #Texas

XBB.1.5 is still the top circulating lineage in TX (#15DayTrends)

14/n

USA Airport surveillance update #15DayTrends

193 sequences from 6 US States (#California, #NewYork, #Washington, #NewJersey, #Georgia and #Virginia) from @CDCgov's Traveler-Based Genomic Surveillance Program.

*Includes pooled swabs & Many bad QC seqs

15/n