Claire McCarthyCheck out some #CoolScienceImages from a Nature Communications study on #fluorescencefriday. Nikolos et al. showed that an iDAMP blockade approach synergizes with #chemotherapy and sensitizes #bladdercancer to #immunotherapy in #preclinicalmodels.
https://www.nature.com/articles/s41467-022-29026-9
Music: Baby Don’t Hurt Me by David Guerra, Anne-Marie, & Coi Leray
#CancerMoonshot
#CancerMoonshotSeminar
#CMSSChan
#cancerresearch
#ImmuneCheckpointBlockade
Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors - Nature Communications
Chemoimmunotherapy recently failed to improve objective response for patients with advanced muscle-invasive bladder cancer (MIBC). Here using two murine models of immune-excluded MIBC, the authors show that resistance to chemoimmunotherapy can be overcome by blocking the COX-2/prostaglandin E2 axis, reinvigorating anti-tumor immune responses.