Claire McCarthyMay 12, 2023

Check out some #CoolScienceImages from a Nature Communications study on #fluorescencefriday. Nikolos et al. showed that an iDAMP blockade approach synergizes with #chemotherapy and sensitizes #bladdercancer to #immunotherapy in #preclinicalmodels.

https://www.nature.com/articles/s41467-022-29026-9

Music: Baby Don’t Hurt Me by David Guerra, Anne-Marie, & Coi Leray

#CancerMoonshot
#CancerMoonshotSeminar
#CMSSChan
#cancerresearch
#ImmuneCheckpointBlockade

Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors - Nature Communications

Chemoimmunotherapy recently failed to improve objective response for patients with advanced muscle-invasive bladder cancer (MIBC). Here using two murine models of immune-excluded MIBC, the authors show that resistance to chemoimmunotherapy can be overcome by blocking the COX-2/prostaglandin E2 axis, reinvigorating anti-tumor immune responses.

Nature
Claire McCarthyJan 26, 2023

ICYMI, earlier today Dr. Heidi Hanson gave a #CancerMoonshotSeminar on Modeling Outcomes using Surveillance data and Scalable #ArtificialIntelligence for Cancer. Her talk discussed building a National Cancer Data Ecosystem, NCI-DOE Collaborations, the MOSSAIC project, scalable models for clinical data extraction, and clinical integration/translation for real-time incidence reporting and #clinicaltrials feasibility assessments. #CMSSHanson

Learn more about MOSSAIC at https://bit.ly/3XFcAWV.

NCI-Department of Energy Collaborations | CBIIT

Since 2016, NCI and the U.S. Department of Energy (DOE) have engaged in a strategic, interagency collaboration to simultaneously accelerate advances in precision oncology and scientific computing. The NCI-DOE Collaboration is part of the Cancer Moonshot℠, dedicated to ending cancer as we know it.

Claire McCarthyNov 18, 2022

Here is a recap of today’s talk by @zeynep on “How to explore cancer #omics datasets.”

She presented iCAVE, an immersive 3D #dataviz tool. https://bit.ly/3XdXYOr

Dr. Gumus also shared the development of tools for #proteomic and immune-related data.
https://bit.ly/3OiLvFl
https://bit.ly/3V4IBpR
https://bit.ly/3V9XBTd

To conclude, she described PRIMAVO, which will enable researchers to explore data from #immunotherapy trials.

#CancerMoonshotSeminar #DataViz4Cancer #CMSSGumus

Software | Gumus Lab

The latest software from the Gumus lab can be viewed on our website