@CastlTrAstonDrs @nature

https://www.barrons.com/articles/merck-covid-pill-risks-51633398722

https://www.bloomberg.com/news/features/2021-03-25/merck-mrk-molnupiravir-pill-could-change-the-fight-against-covid

2021.. we KNEW since 2021 it was a very bad idea! Me #noScienceGirl saw it right away after reading these 2 articles🤦🏻‍♀️
#novavax couldn’t get approval for an eternity but #merck #molnupiravir w/ it’s KNOWN issues..altho issues presented themselves differently & worse than anticipated
#FDA is no longer holds the values of the agency it was when first founded #corruption

The chemical compound on which molnupiravir is based—C9H13N3O6, or N4-hydroxycytidine—has been known for decades. Like idoxuridine, the herpes drug, it’s a nucleoside analogue. It interferes in replication, preventing a threat from causing severe infection. Molnupiravir doesn’t stop the virus from replicating, though; instead, the drug introduces errors into the virus’s RNA that are then replicated until it’s defunct.
With antivirals such as this, “basically you’re going to put a piece of sand in the gears and hope it stops the impact of the virus,” says Gomez, the former Niaid scientist. But, he adds, stopping the virus by creating errors in the genetic code or through other means can come with unintended consequences. “You don’t know where the sand might end up in the other parts of the body.” A company called Pharmasset Inc. (a hepatitis C drugmaker Gilead bought in 2011) investigated molnupiravir’s main ingredient around the turn of the century, but it abandoned development over concerns that it was mutagenic, meaning it could lead to birth defects.

Molnupiravir works by incorporating itself into the genetic material of the virus, and then causing a huge number of mutations as the virus replicates, effectively killing it. In some lab tests, the drug has also shown the ability to integrate into the genetic material of mammalian cells, causing mutations as those cells replicate.
If that were to happen in the cells of a patient being treated with molnupiravir, it could theoretically lead to cancer or birth defects.

Merck’s Covid Pill Could Pose Serious Risks, Scientists Warn

Some scientists say the drug could integrate itself into patients' DNA, theoretically leading to cancer. Merck says its tests show that isn't an issue.

Barrons

@theLUCASTDS
Idiots & sociopaths..
was LITERALLY JUST looking at that🤦🏻‍♀️ And what I was thinking is… money💰💰will not save you & #sars2 is #egalitarian in a sense

Reminds me of my #capitalist dad’s last words to me, “money isn’t the most important thing” to which I replied, “wrong kid” but in retrospect it was meant for me🖤🖤

#covid is a joke to these people meanwhile me #noScienceGirl is reading this type of stuff : https://elifesciences.org/articles/84790

These people will not get it until it’s far far too late🤷🏻‍♀️

SARS-CoV-2 uses CD4 to infect T helper lymphocytes

The infection of T helper lymphocytes by SARS-CoV-2, mediated via the CD4 molecule, alters cellular function and enhances expression of the anti-inflammatory cytokine IL-10, potentially impairing immune response in individuals with COVID-19.

eLife

Here’s a #covidHandout on #cilia
& the link to the #CovidReport study
https://www.cell.com/cell/fulltext/S0092-8674(22)01505-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015057%3Fshowall%3Dtrue

Again, #noScienceGirl but liberal arts aren’t no dummies whatsoever; we live to learn🌈

Last year myself was #hopium on nasal vaccines but heard #osterholm claim success not likely.. there’s some episode he explains why but still hoped..am still hopeful tbh

SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming

Respiratory viruses, including SARS-CoV-2, bypass the defensive mucus/mucin layer of the airway by entering and exiting epithelial cells via their protruding, motile cilia and microvilli.

Cell

https://archive.ph/2023.04.10-211731/https://www.washingtonpost.com/health/2023/04/10/operation-warp-speed-successor-project-nextgen/
there’s a lot of #hullabaloo over this new #whiteHouse initiative & #DanDiamond #WAPO one of my favorite reporters, however there’s some stuff i found problematic & as #noScienceGirl will attempt to address my concerns coherently 🤣

it’s the effort that counts, right?
Yeah, No.

what’s troublesome is article eludes we’re trying to reinvent 🛞when imho we have a pretty decent design already started that needs refinement

engineering fashion not so different to vaccines..😶

once food poisoned myself w/🐓 back in 2011 & #noScienceGirl dumbly did not know about bacteria growth & tbh have no idea how i’ve survived thus far..probs b/c i never cooked prior

poisoned myself late AM but by PM my autonomic system wasn’t working & would stop breathing. also found out where my  were that🌙

my #covid infections & Pfizer 💉💉had identical soreness except instead of 24 hrs, it went on for months

if you want to avoid #dialysis or transplant, advise taking care of kidneys🌈

Idk how other people are understanding the statement #covid is #airborneHIV #airborneAIDS but #noScienceGirl here who DOES have💪🏼#liberalArts background interprets this statement as a metaphor/analogy

my grasp of #biology is weak/nonexistent but hyper interest in aging,avoiding #cancer ,disease & lifelong #germaphobeGalore DO get basic things

Yeah, i get #sarscov2 doesn’t reverse transcript #DNA but again,would gamble w/infection of former vs. latter but #whatever #masklessHoards #youDoYouBoo 🙄

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525456/
i love how the experts are like, “ #Asymptomatic infection is a tricky & uncharted territory for infectious disease immunologists & clinicians” but then some rando on  is an expert on #sarscov2 severity, claims 2020-2021 #variants are super dangerous implying ‘22-‘23 are quite fine🤣😂🤣🤣🤨😐

#noScienceGirl here based on intuition & irl experience is going to have to disagree

my #immuneSystem will never passively accept #alwaysInfected but #youDoYou #justACold 🙄

The immunology of asymptomatic SARS-CoV-2 infection: what are the key questions?

An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. As asymptomatic disease is by definition hard to screen for, there is a lack of clarity about ...

PubMed Central (PMC)