Giuseppe MichieliSep 7, 2023
#Depletion of #BoneMarrow Hematopoietic Cells in #Ebola Virus-Infected Rhesus #Macaques: A Possible Cause of #Hematologic Abnormalities in Ebola Virus Disease https://ajp.amjpathol.org/article/S0002-9440(23)00316-4/fulltext?rss=yes
Depletion of Bone Marrow Hematopoietic Cells in Ebola Virus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebola Virus Disease

The pathophysiology of long-recognized hematological abnormalities in Ebola virus disease (EVD) is unknown. From limited human sampling (of peripheral blood), it has been postulated that emergency hematopoiesis plays a role in severe EVD, but the systematic characterization of the bone marrow (BM) has not occurred in human disease or in nonhuman primate models. In a lethal rhesus macaque (RhM) model of EVD, sternal BMs from eighteen RhMs were characterized after intramuscular exposure to Ebola virus (EBOV) Kikwit as compared to uninfected controls (n=3).

The American Journal of Pathology
halama_immunoJan 2, 2023
New data: One of the few randomized controlled trials #RCT for the #treatment of #COVID19 shows effects for patients with #hematologic malignancies or #solidtumors with more immunological analyses upcoming! #Oncology #immunology #cancer
https://www.nature.com/articles/s43018-022-00503-w
Anti-SARS-CoV-2 antibody-containing plasma improves outcome in patients with hematologic or solid cancer and severe COVID-19: a randomized clinical trial - Nature Cancer

Müller-Tidow and colleagues perform a randomized clinical trial and show that administration of convalescent plasma improves COVID-19 outcome in patients with cancer who are unable to generate an adequate immune response.

Nature
Dave VannessDec 5, 2022

Please spread the word - if you know of any promising second or third-year undergraduate students from underrepresented or disadvantaged backgrounds who are interested in graduate school and research careers in #cardiovascular, #pulmonary, #hematologic, and/or #sleep disorders, please encourage them to apply to the IMPACT program at Penn State: www.impactprogram.psu.edu

Deadline: December 16, 2022

#academia @academicchatter