Bonjour !

J'ai rêvé de l'existence d'une mozzarella estampillée "fromage de test" avec plusieurs niveaux de glutamate.

#fedirêve #gustation

Now out in Current Biology - our attempt at detecting protein homologs in the post-protein folding age.

Insect ORs and GRs are particularly difficult to work with because of rapid evolution and huge sequence divergence. By combining structure and sequence based searches, we surprisingly found homologs across the tree of life. Cryptic proteins as old as LUCA?

https://doi.org/10.1016/j.cub.2023.10.008

#phylogenetics #alphafold #evolution #ionchannels #olfaction #smell #gustation #taste #drosophila #asgard #LUCA

Now live at eLife: Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins

https://elifesciences.org/articles/85537

The first part of a developing project looking into the enigmatic origins of insect Gustatory and Odorant receptors!

#olfaction #smell #taste #gustation #evolution #molecularevolution #phylogenetics #LECA #trypanosoma #drosophila #AlphaFold