halama_immunoJan 7, 2023
Another addition to the toolbox: between #organoids and #explantmodels are the #epitheloids ...self maintaining over a long time, these models recapitulate epithelial structures. #ModelSystem #models #bioengineering #tissue #tissueengineering @schumacher @gpollara
https://www.biorxiv.org/content/10.1101/2023.01.03.522589v1.full
halama_immunoDec 30, 2022
An #assembloid -like model system was used in a cohort of #breastcancer patients to test the utility in #treatments selection...with interesting results, putting approaches with #organoids and #explantmodels in #Oncology to the test for #stratification and #PersonalizedMedicine
@gpollara @cyrilpedia
https://www.pnas.org/doi/10.1073/pnas.2209856120
halama_immunoDec 23, 2022
Building blocks made from living cells...an emergent therapeutic strategy. We still have to find the "treasure chest" of suitable targets and the right order of intervention... #bioengineering #cellulartherapies #tissueengineering #organoids #explantmodels #immunology
https://scim.ag/Xu
Show threadhalama_immunoDec 20, 2022
@gpollara @schumacher thanks for sharing! really excellent work and also brillant to adress this complicated immunological regulation in this specific disease situation.
What really is an advantage of #explantmodels is their excellent comparability to the corresponding human situation (aka "translatability"): https://pubmed.ncbi.nlm.nih.gov/27070705/
Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients - PubMed

The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive …

PubMed
Show threadhalama_immunoDec 20, 2022
@schumacher @gpollara And in addition to organoid systems one can consider #explantmodels that contain the full spectrum of human cells, so you have complexity at the cost of more challenging interventions to test hypotheses ...
Show threadhalama_immunoDec 9, 2022
@tonic In addition one could think about going fully human for more insights: #explantmodels could allow factor identification or deliver modulating supernatant...
https://pubmed.ncbi.nlm.nih.gov/27070705/
Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients - PubMed

The immune response influences the clinical course of colorectal cancer (CRC). Analyzing the invasive margin of human CRC liver metastases, we identified a mechanism of immune cell exploitation by tumor cells. While two distinct subsets of myeloid cells induce an influx of T cells into the invasive …

PubMed
halama_immunoDec 3, 2022
An alternative to #organoids for new #cellulartherapeutics are #explantmodels that guide approaches to overcome resistance mechanisms...an example #Immunotherapy #pancreaticcancer #biotechnology https://www.nature.com/articles/s41551-021-00737-6
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours - Nature Biomedical Engineering

Forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.

Nature