Fetal #cells can be traced back to the first day of #embryonic development.
https://phys.org/news/2024-05-fetal-cells-day-embryonic.html
Though more than 8 million babies have been born through in vitro fertilization (IVF), 70% of IVF implantations fail. As IVF is becoming a more common route to pregnancy in cases of infertility, there is a need for better understanding of embryonic development at this early stage.
"While endogenous #retroviruses (ERVs) are essential for early development..precise role..remains mysterious. Using cutting-edge #genetic & biochemical techniques in mice, we identify MERVL-gag, a retroviral protein, as a crucial modulator of pluripotent factors OCT4 & SOX2 during lineage specification. MERVL-gag tightly operates with URI, a prefoldin #protein that concurs with #pluripotency bias in mouse #blastomeres..required for totipotency-to-pluripotency transition"
"Here we introduce double #emulsion droplet sensors that enable local measurements of #osmotic pressure intra- & extra-cellularly within 3D multicellular systems, including living tissues. After generating & calibrating the sensors, we measure the osmotic pressure in #blastomeres of early #zebrafish embryos as well as in the interstitial fluid between the cells of the #blastula by monitoring the size of droplets previously inserted in the embryo"
Osmotic pressure is thought to play a key role in many cellular and developmental processes, but remains challenging to measure it in cells and tissues. Here, the authors present a sensor based on double emulsion droplets that allows quantification of osmotic pressure in situ and in vivo.
CellBioNews
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