Triptorelin associated adverse events evaluated using FAERS pharmacovigilance data
Our pharmacovigilance study represents the first comprehensive analysis of triptorelin’s post-marketing safety profile using FAERS data. The identificationof…
#NewsBeep #News #Headlines #Adverseevents #Cancer #endocrinology #FAERS #HumanitiesandSocialSciences #Latvia #LV #Medicalresearch #multidisciplinary #Pharmacovigilance #Science #Triptorelin
https://www.newsbeep.com/95734/
The claim is circulating that antidepressants can cause overheating and dehydration. This is a genuine public health message, but it's not so simple: diuretics, beta blockers, ACE inhibitors, antipsychotics, and some antihistamines may also interact badly with hot weather.
https://www.nytimes.com/2024/06/15/well/live/heat-weather-medication-safety.html (excerpt in a reply)
There's even doubt about antidepressants having this effect. A recent paper in eClinicalMedicine looked at all the studies they could find and concluded that there wasn't evidence of antidepressants causing overheating in hot weather - though some other medicines do.
"Current evidence supports strong anticholinergics, non-selective beta-blockers, adrenaline, and anti-Parkinson’s agents impairing thermoregulation during heat stress ... physicians should interpret with caution conventional public health messaging related to the thermoregulatory effects of some drugs (e.g., antidepressants) during hot weather."
https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00465-6/fulltext
#Antidepressants #Diuretics #AnticholinergicMedications #MedMastodon #BetaBlockers #HeatWaves #Thermoregulation #OverHeating #Dehydration #SideEffects #AdverseEffects #AdverseEvents #DrugSideEffects #DrugSafety #HeatStress #HotWeather #HotWeatherSafety #PublicHealth #ACEinhibitors #Antipsychotics
Given my earlier work on the reporting of harms https://www.researchgate.net/profile/Tom-Kindlon/research I was informed of an upcoming special issue of Trials on assessing #harms in clinical trials, "The collection, analysis and reporting of adverse events in randomised controlled trials"
https://www.biomedcentral.com/collections/CART
These days I focus on @IrishMECFSAssociation but perhaps of interest to somebody. With all the exercise and other #LongCovid trials, it remains important
Our main paper reporting the results of our #MultiSite observational study investigating the effectiveness of #psychotherapy in patients with #MedicallyUnexplained #PhysicalSymptoms in #CzechRepublic services has been published:
https://link.springer.com/article/10.1007/s10879-023-09597-4
#Rstats codes and materials: https://osf.io/dfrma/
This completes the trio, w prev papers looking at #NegativeEffects https://discovery.dundee.ac.uk/en/publications/negative-effects-during-multicomponent-group-based-treatment-a-mu #AdverseEvents
and our exploration of potential mechanisms of change
https://discovery.dundee.ac.uk/en/publications/mechanisms-of-change-in-multicomponent-group-based-treatment-for-
Abstract Psychotherapy is expected to be effective in the treatment of patients with medically unexplained physical symptoms (MUPS). However, evidence is scarce. The aim of this study was to examine the effectiveness of a multicomponent treatment based on group therapy in patients with MUPS in a naturalistic setting and to explore potential predictors of the outcomes. A multisite naturalistic uncontrolled effectiveness study. A total of 290 patients with MUPS participated in group psychotherapy across seven clinical sites. Somatic symptoms, depression, anxiety, general psychotherapy outcomes operationalized as the Outcome Rating Scale (ORS) score, well-being, role functioning interference, as well as a number of pretreatment predictors were measured using a battery of self-report measures. Multilevel modeling and lasso regression with bootstrapping were used for the analysis. Medium to large pre-post effects were found for somatic symptoms, ORS, depression, anxiety, well-being, role functioning interference found in completers after controlling for site and group effects, pretreatment outcome values, and treatment length. Changes reported at 6- and 12-month follow-up were higher for most variables. No substantial pretreatment predictors of the patients’ posttreatment status were found in addition to the pretreatment level of outcome variables. Somatic symptoms seem to be less malleable in psychotherapy than psychological outcome variables. However, there was a trend of further improvement after treatment completion. Registration This study was retrospectively registered with ISRCTN (Identifier 13532466).
A straight-forward summary of the vaccine adverse event study is now on this website https://www.contagionlive.com/view/large-new-zealand-study-confirms-safety-profile-of-pfizer-biontech-vaccine
Will be interesting to see how the community here responds to this careful epidemiological study of the #adverseEvents following the first two rounds of #COVID vaccination in #aotearoa #newZealand, a highly vaccinated population with almost no covid infection at that time
Risk of prespecified adverse events was measured by linking vaccination and hospitalisation records, vs historical rates 2014 - 2019.
News Beep
Matt Hodgkinson
WikiPathways
Tom Kindlon
Jan R. Boehnke
James Harris 
