WikiPathwaysJul 18, 2024
A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis. https://doi.org/10.20411/pai.v9i2.705 #AdverseEvents #Linezolid #Neurotoxicity #PrecisionMedicine #Sbsn
A Transcriptomic Biomarker Predicting Linezolid-Associated Neuropathy During Treatment of Drug-Resistant Tuberculosis | Pathogens and Immunity

Gabriele PollaraSep 9, 2023

Linezolid probably a bit safer than we think & probably can give >4 weeks with close observation.

Great drug, it's oral, but still makes me a bit apprehensive about using it for a long course, certainly at 600mg BD.

#IDMastodon #MedMastodon #AMR #antibiotics #microbiology #medicine #linezolid

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects | Journal of Antimicrobial Chemotherapy | Oxford Academic https://academic.oup.com/jac/advance-article/doi/10.1093/jac/dkad276/7264092

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects

AbstractObjectives. Antibiotic treatment for bone and joint infections generally lasts for 6 weeks or longer. Linezolid may be a good option for treating bone a

OUP Academic
Gabriele PollaraMar 24, 2023

Actually quite low risk of serotonin syndrome when using #Linezolid in patients on antidepressants!

#antibiotics #IDMastodon #microbiology #AMR #MedMastodon

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799688

Linezolid and Risk of Serotonin Syndrome in Patients Receiving Antidepressants

This cohort study examines the incidence of serotonin syndrome among patients receiving linezolid treatment while taking an antidepressant compared with those not taking an antidepressant.

Art WalaszekDec 21, 2022

Good news:

- the risk of #serotonin syndrome is low in hospitalized older adults treated with #linezolid (around 0.5%)
- antidepressants do not increase the risk of serotonin syndrome in these patients

So, being on an #antidepressant should not be a contraindication to receiving linezolid and antidepressants do not need to be stopped when linezolid is prescribed.

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799688

#MedMastodon #GeriMastodon #Psychiatry

Linezolid and Risk of Serotonin Syndrome in Patients Receiving Antidepressants

This cohort study examines the incidence of serotonin syndrome among patients receiving linezolid treatment while taking an antidepressant compared with those not taking an antidepressant.