German Scientists Cure HIV-Infected Human Lymphocytes – The Blog of Science

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

Long covid: What we now know about its causes and possible treatments

Almost four years after the first cases emerged, we are accumulating evidence about the physiology behind this complex condition – from microclots to viral persistence

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC) - Nature Immunology

Proal and colleagues review the evidence for long-term persistence of coronavirus SARS-CoV-2 in tissues of infected individuals and discuss how this viral reservoir may contribute to the pathogenesis of post-acute sequelae of COVID-19 (PASC).

HIV proviral genetic diversity, compartmentalization and inferred dynamics in lung and blood during long-term suppressive antiretroviral therapy

Author summary HIV persists in the body despite long-term antiretroviral therapy (ART). Much of our knowledge about the HIV reservoir comes from studying blood proviruses on ART, but a fundamental question is whether these are distinct from those in tissue. The lung could theoretically engender genetically distinctive HIV populations, but this remains understudied. Our analysis of nearly 900 subgenomic proviral sequences from blood and lung of individuals receiving long-term HIV therapy revealed substantial within-host heterogeneity, yet some common patterns. Identical sequences (consistent with clonal expansion of infected cells) were observed in everyone, though at varying (8–86%) frequencies. The same sequence was often recovered from both blood and lung (77% of participants). Only a subset of individuals exhibited blood-lung genetic compartmentalization, and only modestly so, where this compartmentalization was sometimes due to differential frequencies of identical sequences, not the presence of truly genetically distinctive populations, across sites. Blood proviral diversity mirrored that in lung, indicating that strategies to limit the former (e.g. early ART) should also limit the latter. Results also revealed evidence that blood and lung proviruses can persist for >20 years within-host, and that viruses emerging in blood during treatment interruptions can re-seed both lung and blood reservoirs.