Mastodawn

New Weapon Against Breast Cancer. A new, supercharged form of immunotherapy for breast cancer has just been announced by UCLA oncologists. #immunotherapy #CARNKT #cancer #breast #triplenegative #ovarian #pancreatic #lung
https://www.instagram.com/p/DQdod3Mj3HW/

Howard G. Smith MD, AM on Instagram: "#deafness #children #congenital #otoferlin #dboto deafness, children, congenital, otoferlin, dboto ========================== FUTURE MED ========================== New Weapon Against Breast Cancer A new, supercharged form of immunotherapy for breast cancer has just been announced by UCLA oncologists in the Journal of Hematology & Oncology. The new approach involves the production of CAR-NKT cells, standing for chimeric antigen receptor-natural killer T cells, that have the superpower to attack not one but dozens of tumor cell surface antigens simultaneously. The cells target a protein mesothelin, which cancers need to rapidly grow and spread. Many current immunotherapies only target a single receptor. Triple negative breast cancers lack many of these common receptors making them difficult to treat successfully. This CAR-NKT therapy attacks so many receptors it could prove effective for those with these triple negative cancers. Even better, the CAR-NKT cells can be mass-produced from donated stem cells and stored for immediate use on demand. Very promising is the fact that the CAR-NKT cells target, mesothelin, is not only found on breast cancers but also on the surfaces of ovarian, pancreatic, and lung cancer cells. So far, these CAR-NKT cells have only been tested in the laboratory on tissue cultured breast cancer cells harvested from patient swith advanced disease. Clinical trials are in the planning stages, and hopefully, this super-immunotherapy will be available to save patients with a variety of difficult-to-treat cancers…..someday soon. https://www.news-medical.net/news/20251022/New-type-of-immunotherapy-could-change-the-treatment-plan-for-triple-negative-breast-cancer.aspx https://jhoonline.biomedcentral.com/articles/10.1186/s13045-025-01736-9 #immunotherapy #CAR-NKT #cancer #breast #triplenegative #ovarian #pancreatic #lung"

UCLA scientists have made a significant breakthrough in the fight against triple-negative breast cancer with the discovery of a super-immunotherapy. This revolutionary treatment uses CAR-NKT cells to attack multiple tumor cell antigens, offering new hope for patients with this aggressive form of breast cancer. The CAR-NKT cells can be mass-produced from donated stem cells and stored for immediate use, making it a promising treatment option for those with triple-negative breast cancer.

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Rihards Olups Aug 31, 2024

English and it's "Oh noes, a double negative! What will we do!".

This graffiti in Riga could be translated as "Nobody has not said nothing", and it makes perfect sense in Latvian.

#Latvian #DoubleNegative #TripleNegative #language

PLOS Biology Aug 3, 2023

.@FengYang_MedBio &co show that #MAPK4 promotes PDK1 protein synthesis and thus also activates PDK1 substrates beyond AKT to promote #cancer. Co-targeting AKT & PDK1 may help treat MAPK4-high cancers like "#TripleNegative" #BreastCancer #PLOSBiology https://plos.io/43NCCK0

Cooperative activation of PDK1 and AKT by MAPK4 enhances cancer growth and resistance to therapy

This study shows that besides activating AKT, MAPK4 promotes PDK1 protein synthesis and thus also activates PDK1 substrates beyond AKT to promote cancer. Co-targeting AKT and PDK1 can therefore repress MAPK4-induced cancer cell growth, suggesting a potential therapeutic strategy to treat MAPK4-high cancers, including a large subset of "triple negative" breast cancer.

Nick Byrd, Ph.D.Mar 1, 2023

"Five of [seven intelligence] agencies determined it... 'very unlikely' that a foreign adversary was responsible for [#HavanaSyndrome] symptoms..."

"One agency ...determined that it was 'unlikely'."

"One agency abstained in its conclusion regarding a foreign actor."

"...when asked, no agency dissented from the conclusion that a foreign actor did not cause the symptoms...."

https://apnews.com/article/havana-syndrome-intelligence-anonalous-health-incidents-diplomats-cf087b8255532056b5597232544bfb71

#IntelligenceCommunity #LikertScale #Probability #DoubleNegative #TripleNegative?

Intel agencies: No sign adversaries behind 'Havana syndrome'

WASHINGTON (AP) — U.S. intelligence agencies cannot link a foreign adversary to any of the incidents associated with so-called “Havana syndrome,” the hundreds of cases of brain injuries and other symptoms reported by American personnel around the world.

Associated Press