John Vaccaro (johniac)Feb 2, 2025

SciTech Chronicles. . . . . . . . .Feb 2nd, 2025

https://bit.ly/stc020225

#AM #gastrointestinal #mucus #glycan #mucin #Alzheimer’s #amyloid #Talin #Tau #APP #photothermal #polyaniline #polydopamine #durability #thermogalvanic #Iron #scalability #stability #seismometers #uncontrolled #Chinese #SpaceX #damage

SciTech Chronicles. . . . . . . . .Feb 2nd, 2025

  Though I am an old man, I am forever a young gardener. Vol II No 28 167 links Curated Healthy gut bacteria that feed on sugar analyzed htt...

CellBioNewsFeb 2, 2024

How #talin #protein maintains #intercellular connection while transmitting force.

https://phys.org/news/2024-02-talin-protein-intercellular-transmitting.html

How talin protein maintains intercellular connection while transmitting force

In multicellular organisms, cell migration and mechanosensing are essential for cellular development and maintenance. These processes rely on talin, the key focal adhesion—or FA—protein, central in connecting adjacent cellular matrices and enabling force transmission between them.

Phys.org
Pereda LabJul 12, 2023
Paper by Ueda et al "Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1" in iScience @iScience
https://www.cell.com/iscience/fulltext/S2589-0042(23)01369-X
The role of talin1 in cell polarization, downstream of Rap1, seems to be independent of talin binding to integrins and of integrin adhesion
#Rap1 #talin #cytoskeleton #GEFs #GAPs
Julien DelpierreNov 10, 2022
"Single-molecule magnetic tweezers to capture over a million individual transitions as a single talin protein unfolds and refolds under force in equilibrium. When observed at classically probed timescales, talin folds in an apparently uncomplicated two-state manner. As the sampling time extends from minutes to days, the underlying energy landscape exhibits gradually larger signatures of complexity, involving a finite number of well-defined rare conformations.[...]The physiological relevance of each distinct conformation can be connected to the binding of the cytoskeletal protein vinculin, suggesting an extra layer of complexity in talin-mediated mechanotransduction."
https://www.nature.com/articles/s41567-022-01808-4
#StructuralBiology #Talin #Vinculin #MechanoTransduction #MechanoBiology #Cytoskeleton
Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape - Nature Physics

Single-molecule magnetic tweezers enable probing the folding dynamics of a single talin protein for long periods of time. This allows the observation of previously inaccessible rare and kinetically trapped conformations.

Nature