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#glycan #protein #glycotime

SciTech Chronicles. . . . . . . . .Feb 2nd, 2025

  Though I am an old man, I am forever a young gardener. Vol II No 28 167 links Curated Healthy gut bacteria that feed on sugar analyzed htt...

Structural and immunological characterization of the #H3 #influenza #hemagglutinin during #antigenic #drift, BioRxIV: https://www.biorxiv.org/content/10.1101/2024.09.13.612776v1

In this study, we explore the influence of #glycan #evolution on H3 hemagglutinin from 1968 to present day and its impacts on antigenicity and immunogenicity.

📢Got questions about #glycan #microarrays, and their data analysis? We are hosting an Ask Us Anything session, where you can ask us your questions.
Note - this is not a seminar.
Join us on: September 23rd, 2024 10am-11am ET
Sign up for Zoom:
https://forms.gle/LsAYLusyMGa3Heet9
#glycotime
Ask Us Anything September 23, 2024

Event Timing: September 23, 2024 drop-in anytime between 10AM-11AM EST The NCFG is hosting an "Ask Us Anything" event for any questions you may have about glycan microarrays, data analysis and functional glycomics. Please signup for the NCFG "Ask Us Anything" to receive the Zoom link closer to the event. Please Note - this is not a presentation. This is an open forum for you to ask questions.

Google Docs

`We report a fluorinated azido-coumarin scaffold which enables #photolabeling under fast and mild activation, and which can leave a #fluorescent tag on crosslinked species. Coupling this scaffold to an α-fucoside, we demonstrate fluorogenic photolabeling of #glycan-#protein interactions over a wide range of affinities. We expect this strategy to be broadly applicable to other #chromophores and we envision that such “fluoro-crosslinkers” could become important tools`

https://onlinelibrary.wiley.com/doi/10.1002/anie.202314248

📢#Glycoscience Community on Mastadon.
Are you attending the Society for Glycobiology meeting in Hawaii? Find us and learn about the work at the NCFG and the Cummings Lab.

1. We are hosting a Satellite meeting on Nov. 5th, entitled: NCFG Tools in Glycoscience, we hope you will be joining us!

2. Come check out our posters at the SFG meeting:
#155, #401, #67, #79, #89, #224, #170, and #225
We have some interesting developments in #glycan #microarrays, #glycomics and other fun stuff!

Papers in press time at jbiolchem! Periscope protein adhesin domain structures-an incredible effort by all my excellent colleagues. Structures reveal lectin homology domains, but...here's the kicker - no evidence of #glycan binding. 🤔 #Proteins #crystallography

https://www.jbc.org/article/S0021-9258(23)00068-6/fulltext

An #introduction into our work on #glycotime! We are a lab joint between the Francis Crick Institute and the Department of Chemistry at Imperial College London. We develop what we call chemical "precision tools" to investigate protein #glycosylation. These tools are specific for individual #glycosyltransferases, #glycan subtypes or cell lines. We employ methods of #chembio including #OrgChem, protein engineering, #glycoproteomics, #imaging, #chemoenzymatic synthesis and drug discovery.