Mastodawn

Ron Beavis ❌Jan 26, 2024

α⧸ω ST phosphorylation diagrams for human & mouse mediator complex subunit 29 (#MED29:p, aka #MED2:p). Unlike #MED1:p, this sequence does not use phosphorylation, even though its only has a few, scattered helical domains. Much of the information about this gene is buried in the 'zines under the subunit's older (but salacious) name "Intersex-like, IXL" (e.g., Kuuselo, 2007 https://pubmed.ncbi.nlm.nih.gov/17332321/) #proteomics #mediator

Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification - PubMed

Pancreatic cancer is a highly aggressive disease characterized by poor prognosis and vast genetic instability. Recent microarray-based, genome-wide surveys have identified multiple recurrent copy number aberrations in pancreatic cancer; however, the target genes are, for the most part, unknown. Here …

PubMed

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Ron Beavis ❌Jan 25, 2024

What is now #MED1:p has gone under many names in the 'zines, making the written accounts of its adventures difficult to navigate. Also known as: Activator-recruited cofactor 205 kDa component; Peroxisome proliferator-activated receptor-binding protein; Thyroid hormone receptor-associated protein complex 220 kDa component; Thyroid receptor-interacting protein; Vitamin D receptor-interacting protein complex component; & p53 regulatory protein RB18A. #proteomics #mediator

Ron Beavis ❌Jan 25, 2024

α⧸ω ST phosphorylation diagrams for human & mouse mediator complex subunit 1 (#MED1:p). Both sequences are have an nward structured domain, followed by a complex, multiple acceptor phosphoIDR that extends to the C-terminus. In addition to phosphorylation, this region features a number of interesting low complexity domains. #proteomics #mediator