RT @: Looking for an interesting read on a lazy Sunday? Check out our #preprint on a new #proteomics workflow for analysis of Tyr #sulfation. Novel sTyr proteins include both glycan and protein sulfotransferases. @Pseudoenzyme @andy___jones @c4pr_liv
#ABA is vital to #plant stress tolerance, but long-term overactivation of ABA signaling suppresses #growth and #development. Here, Wang et al. reveal a protein #sulfation mechanism that desensitizes ABA response. https://doi.org/10.1111/jipb.13493
@wileyplantsci
#JIPB #PlantScience #Arabidopsis

Last year the Longevity Prize offered a $20k Hypothesis Prize. I submitted something since I figured its probably better odds than the lottery. The submission was due at end of last year, but so far no updates to the page & no announcement of a winner. Whatever.🤷

I was left completely drained by the effort - but I learned a lot of fascinating things.

Here's my submission:
https://docs.google.com/document/d/155hOVv31MyPoyaEscQ-hOtqg2n3a6ETp6cndYlRb0Nw/edit?usp=sharing

#Aging #health #neuroscience #GutMicrobiome #CS2 #sulfation #CarbonDisulfide

CS2 & aging - copy

Carbon Disulfide and Aging Hypothesis: Endogenous carbon disulfide production changes during aging and these changes are associated with alterations in neurological and immune function. Rhyothemis princeps 30 December 2022 Carbon disulfide (CS2) is a volatile liquid at room temperature; its v...

Google Docs
“These sulfated steroid hormones, probably altering neurotransmission, produce an increase in longevity, through common factors to germline-less animals. The fact that the enzymes involved in the sulfate modification of steroid hormones ... are expressed in sensory neurons suggests that alteration the sulfated state of hormones may acts in the integration of environmental cues ...with the reproductive status..." https://doi.org/10.1038/s41467-020-20269-y

#aging #longevity #sulfation
A short account of a recent paper led by Steve Butler on the development of a europium (III) radiometric sensor for PAP/PAPS. Of interest to #GlycoTime #Sulfation #Sulfotransferase #HighThroughput https://ferniglab.wordpress.com/2022/11/08/real-time-sulfotransferase-assay/
Real-time sulfotransferase assay

Ferniglab Blog