There's a new Parkinson disease research article out that I just started reading, but I'm dismayed by the very first sentence in the abstract.

"Exposure to carbon disulfide (CS2) is a recognized risk factor in the pathogenesis of Parkinson’s disease, yet the underlying mechanisms of deleterious effects on mitochondrial integrity have remained elusive. "

Although exposure to CS2 causes parkinsonism, CS2 exposure isn't a recognized risk factor for PD. However,
a case could be made
for a link between chronic CS2 exposure and multiple system atrophy.

The article is:

Liu et al. (2024)
Mitochondrial transfer of α-synuclein mediates carbon disulfide-induced mitochondrial dysfunction and neurotoxicity
https://doi.org/10.1016/j.ecoenv.2024.116613

Here's a link to my hypothesis paper on CS2 and aging which reviews the harms of CS2 and provides supporting references:
https://docs.google.com/document/d/155hOVv31MyPoyaEscQ-hOtqg2n3a6ETp6cndYlRb0Nw/edit?usp=sharing

I will probably post more on Liu et al. 2024 after I get a chance to really study it.

#Parkinsons #CarbonDisulfide
#neuroscience

The Surprisingly Dangerous Story of Viscose
https://youtu.be/0pJwJCwvYiI?si=DJLKR6UqRYIU096B

#Viscose #Rayon #Environment #OccupationalHealth #CarbonDisulfide

Last year the Longevity Prize offered a $20k Hypothesis Prize. I submitted something since I figured its probably better odds than the lottery. The submission was due at end of last year, but so far no updates to the page & no announcement of a winner. Whatever.🤷

I was left completely drained by the effort - but I learned a lot of fascinating things.

Here's my submission:
https://docs.google.com/document/d/155hOVv31MyPoyaEscQ-hOtqg2n3a6ETp6cndYlRb0Nw/edit?usp=sharing

#Aging #health #neuroscience #GutMicrobiome #CS2 #sulfation #CarbonDisulfide

“She was given Antabuse to treat her alcoholism, but an autopsy upon her death (which was due to falling from a window, not cancer) revealed that her body was clinically cancer-free despite having no further cancer treatment.”

She fell from a window. 🤔

https://www.newsweek.com/cancer-treatment-drug-alcoholism-antabuse-742864

#disulfiram #CarbonDisulfide #DrugRepurposing #SideEffects