preLights“This work demonstrates the influential role of the cellular milieu on cellular organization and highlights glutamate as a modulator of intermolecular clustering interactions.”
Excellent first preLight post written by Erich Sohn covering work from Mrityunjoy Kar and colleagues #PappulabWashU, #SeidelLab #KnowlesLabCamb #HymanLab
#preLight 👉 https://prelights.biologists.com/highlights/glutamate-helps-unmask-the-differences-in-driving-forces-for-phase-separation-versus-clustering-of-fet-family-proteins-in-sub-saturated-solutions-v3/
#preprint #fet #fus #llps #condensate #glutamate #microscopy
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions - preLights
Kar, et al. examine the effect of different ions on the behavior of a self-associative protein to better understand organization within the cell. The authors find that bulky ions, which are particularly abundant and relevant inside the cell, support